Reference

Vinpocetine enhances retrieval of a step-through passive avoidance response in rats

Vinpocetine enhances retrieval of a step-through passive avoidance response in rats. DeNoble, Victor J. (Ayerst Lab. Res., Inc., Princeton, NJ 08543-9990, USA). Pharmacol., Biochem. Behav., 26(1), 183-6 (English) 1987. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Vinpocetine [42971-09-5], vincamine [1617-90-9], apovincaminic acid [27773-65-5], vinconate [70704-03-9], aniracetam [72432-10-1], Hydergine [8067-24-1], and pemoline [2152-34-3] were evaluated for their ability to enhance retrieval of a step-through passive avoidance response in rats. The percentage of rats performing the avoidance response was found to decrease as a function of the no. of days between training and retention testing. 2152-34-3 and 70704-03-9 which are cas registry numbers of chemicals are mentioned. Vinpocetine, administered 60 min prior to testing for retention, increased the no. of rats performing the passive avoidance response. Retrieval enhancement was dose-related in an inverted U-shaped function with the EDs at 18 and 30 mg/kg orally. In contrast, apovincaminic acid, vincamine, vinconate, aniracetam, Hydergine, and pemoline were not effective. These data support the view that vinpocetine has cognition-activating abilities as defined in an animal model of memory retrieval. .

Prolongation of latencies for passive avoidance responses in rats treated with aniracetam or piracetam

Prolongation of latencies for passive avoidance responses in rats treated with aniracetam or piracetam. Yamada, Katsushi; Inoue, Takato; Tanaka, Mariko; Furukawa, Tatsuo (Sch. Med., Fukuoka Univ., Fukuoka 814-01, Japan). Pharmacol., Biochem. Behav., 22(4), 645-8 (English) 1985. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Effects of aniracetam (1-anisoyl-2-pyrrolidone) [72432-10-1] and piracetam (1-acetamido-2-pyrrolidone) [7491-74-9] on passive avoidance behavior were studied in 2- and 18-mo-old rats by a step-down passive avoidance task. Repeated administration of aniracetam (30 and 50 mg/kg) or piracetam (100 mg/kg) i.p. daily for 5 days prolonged step-down latencies for a passive avoidance task in 2-mo-old rats. Administration of aniracetam (50 mg/kg, i.p.) or piracetam (100 mg/kg, i.p.), however, did not affect locomotor activity. This prolongation of latencies was also seen with oral administration of aniracetam (50 mg/kg/day for 5 days). Similar prolongation of latencies also occurred in 18-mo-old rats treated with aniracetam (50 mg/kg i.p. daily for 5 days). The results imply that aniracetam may improve learning and/or memory and 2- and 18-mo-old rats.