Detail of "72487-35-5"

CAS Number:
72487-35-5
Name:
Benzamide,2-hydroxy-5-[(1S)-1-hydroxy-2-[[(1R)-1-methyl-3-phenylpropyl]amino]ethyl]-,hydrochloride (1:1), rel-
Molecular Structure:
Formula:
C19H24 N2 O3 . Cl H
Synonyms:
Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-,monohydrochloride, (R*,S*)- (9CI); Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-,monohydrochloride, (R*,S*)-(?à)-

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Diastereoisomers A by racemic separation of 5[1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl]salicylamide: Diastereoisomers A by racemic separation of 5[1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl]salicylamide. Goold, Elijah H.; Chang, Wei (Scherico Ltd., Switz.). Ger. Offen. DE 2616403 28 Oct 1976, 16 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C103-26. PRIORITY: US 75-569043 17 Apr 1975. DOCUMENT TYPE: Patent CA Section: 25 (Noncondensed Aromatic Compounds) Racemic 4,3-(HO)(H2NCO)C6H3CH(OH)CH2NHCMMeCH2CH2Ph (I) was sepd. into the higher melting (II) and lower-melting (III) diastereomers by 4-MeC6H4SO3H (IV). I was heated with IV and AcOH in MeCHOH, and upon cooling the soln. the salt of III with IV crystd. Addn. of HCl to the mother liquor caused the crystn. of II. 61466-68-0 and 72487-35-5 which are cas registry numbers of chemicals are mentioned.HCl. Refluxing of III.HCl with HCl isomerized it to II.HCl, which has the same action on heart arrhythmia as the racemate but significantly lower .alpha.- and .beta.-receptor blocking and hypotensive action. .