Detail of "72522-13-5"

Reference

Studies on the optimum dosage form for rectal administration of eptazocine

Studies on the optimum dosage form for rectal administration of eptazocine. Kanamoto, Ikuo; Takamatsu, Shigeki; Adachi, Isao; Horikoshi, Isamu; Koizumi, Tamotsu (Dep. Hosp. Pharm., Toyama Med. Pharm. Univ. 930-01, Japan). Drug Delivery Syst., 6(6), 443-7 (Japanese) 1991. CODEN: DDSYEI. ISSN: 0913-5006. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Three kinds of eptazocine HBr (EP) suppositories were prepd. by fusion method: oleaginous-base conventional type (C-type), oleaginous hollow type (H-type) and polyethyelene glycol type (PEG-type). Release tests in vitro were carrier out according to Muranishi's method, and rectal absorptions of EP contained in three kinds of suppositories were investigated using four rabbits. The release rate of EP from H-type was larger than those from the other two kinds of suppositories in early phase, whereas the cumulative release percentage from PEG-type showed the highest value of 300 min. 72522-13-5 and 72150-17-5 are cas registry numbers of chemicals which are used as reagents here. In the rectal absorption studies, the max. plasma concn. (Cmax) of PEG-type was about a fourth of those of the other suppositories. And the other two kinds of oleaginous base suppositories gave significantly shorter Tmax (the time to reach Cmax) than that of PEG-type. The mean bioavailability of C-type, H-type and PEG-type was 61.1, 36.6, and 18.2%, resp. These results suggest that C-type and H-type may be put to good use as a rectal dosage form of EP. .