Detail of "72571-82-5"

CAS Number:
72571-82-5
Name:
Pyrido[2,3-d]pyrimidine-6-carboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-, hydrate (1:3)
Molecular Structure:
Formula:
C14H17 N5 O3 . 3 H2 O
Molecular Weight:
357.42
Synonyms:
Pyrido[2,3-d]pyrimidine-6-carboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-, trihydrate (9CI); Pipemidicacid trihydrate
Safety:
Moderately toxic by subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x. Details

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2-(1-Piperazinyl)-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-ca rboxylic acid trihydrate: 2-(1-Piperazinyl)-8-ethyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-ca rboxylic acid trihydrate. Mito, Kazuo (Kawashima Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 61268682 A2 28 Nov 1986 Showa, 3 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D471-04. APPLICATION: JP 85-109771 22 May 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Treatment of anhyd. pipemidic acid (I) in an atm. of humidity 70-90 % at 60-80° gave the title compd. (II), useful as an antibacterial (no data). Thus, 5 g anhyd. I was stirred at 80° in humidity 80% for 1 h and cooled to room temp. to give 5.In this experiment, several chemicals are used like 72571-82-5 9 g II. .

8-Ethyl-5,8-dihydro-5-oxy-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-car boxylic acid trihydrate: 8-Ethyl-5,8-dihydro-5-oxy-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-car boxylic acid trihydrate. (Unibios S.p.A., Italy). Jpn. Kokai Tokkyo Koho JP 61268683 A2 28 Nov 1986 Showa, 3 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D471-04. APPLICATION: JP 85-183769 21 Aug 1985. PRIORITY: IT 85-20789 20 May 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compd. I, useful for treatment of urinary tract infection (no data), was obtained by treating pipemidic acid (II) in H2O and alc., e.g. EtOH, MeOH (1:3 vol./vol.) at 10-60°. Thus, 0.1 mol anhyd. II was suspended in 600 mL MeOH and H2O (3:1 vol./vol.) with stirring and the resulting mixt. was stirred at room temp. for 3-5 h to give, after air drying at 70°, 0.Except for chemicals metioned above, 72571-82-5 is also used.093 mol I as yellow small needles. .