Detail of "7261-97-4"

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A comparison of the effects of baclofen and some other muscle relaxants on a-rigidity in rats

A comparison of the effects of baclofen and some other muscle relaxants on a-rigidity in rats. Kawajiri, Shinichi; Kojima, Hiroshi; Akashi, Akira (Res. Inst., Daiichi Seiyaku Co. Ltd., Tokyo 134, Japan). Nippon Yakurigaku Zasshi, 83(3), 263-8 (Japanese) 1984. CODEN: NYKZAU. ISSN: 0015-5691. 439-14-5 and 58-25-3 are cas registry numbers. These chemicals are also mentioned in this article. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Baclofen [1134-47-0] and dantrolene [7261-97-4] intraduodenal (i.d.) administration suppressed sustained rigidity of forelimbs in rats with cerebral ischemia. ED50 of baclofen was 2.9 mg/kg and of dantrolene was 22 mg/kg. Baclofen, dantrolene, and diazepam [439-14-5] reduced the phase rigidity of the decerebrated animals with i.d. ED50 of 6.2, 140, and 1.4 mg/kg, resp. Both rigidities were insensitive to chlorodiazepoxide [58-25-3] and tolperisone [728-88-1]. Except for tolperisone, these drugs also produced muscle relaxation in intact rats and mice. The ED50 values of orally administered baclofen, dantrolene, diazepam, chlordiazepoxide, and tolperisone were 5.6, 15.0, 2.1, and 44.0 mg/kg, resp. in mice. .

In vivo induced malignant hyperthermia in pigs

In vivo induced malignant hyperthermia in pigs. I. Physiological and biochemical changes and the influence of dantrolene sodium. Verburg, M. P.; Oerlemans, F. T. J. J.; Van Bennekom, C. A.; Gielen, M. J. 9013-02-9 and 9025-10-9 are cas registry numbers. These chemicals are also mentioned in this article. M.; De Bruyn, C. H. M. M.; Crul, J. F. (Dep. Anaesthesiol., De Wever Hosp., Heerlen 6401 CX, Neth.). Acta Anaesthesiol. Scand., 28(1), 1-8 (English) 1984. CODEN: AANEAB. ISSN: 0001-5172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 Malignant hyperthermia (MH) in pigs was induced with 3% halothane plus a bolus injection of succinylcholine. In the prechallenge period a significant difference was obsd. in the concn. of certain muscle metabolites, comparing the MH-susceptible (MH+) with the nonsusceptible (MH-) pigs. A lower level was measured for phosphocreatinine(PCr) and IMP, and an increased level of lactate and creatine(Cr) in the susceptible pigs (MH+). The challenge caused a significant redn. of the level of PCr and adenosine in MH+ pigs, compared with the prechallenge period. After administration of dantrolene [7261-97-4], a significant decrease was measured in the level of lactate, compared to the prechallenge period as well as during the challenge. In contrast, in the control pigs no significant changes were obsd. in muscle metabolites, either after induction of MH or after the administration of dantrolene sodium. Enzyme activity detns. of muscle adenylate kinase [9013-02-9] and adenosine monophosphate deaminase [9025-10-9] did not show any difference in activity either before or during the MH crisis or after treatment with dantrolene sodium. The earliest physiol. change during an induced MH crisis was the rapid increase of the end-tidal CO2. Within 5 min after MH induction, end-tidal CO2 was doubled. Monitoring of the end-tidal CO2 is essential to diagnose MH at a very early stage. .