Detail of "7288-28-0"

Reference

Synthesis of 3'-ethynylthymidine, 3'-vinylthymidine, and 3'-bromovinylthymidine as potential antiviral agents

Synthesis of 3'-ethynylthymidine, 3'-vinylthymidine, and 3'-bromovinylthymidine as potential antiviral agents. Sahlberg, Christer (Medivir AB, Huddinge S-141 44, Swed.). Tetrahedron Lett., 33(5), 679-82 (English) 1992. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) The synthesis of three novel 3'-unsatd. carbon analogs of AZT and 3'-fluoro-3'-deoxythymidine, is described. 7288-28-0 and 140209-47-8 are also in the experiment. The key step in the synthesis is a Cu(I)-catalyzed addn. of CH2:CHMgBr to a 2,3-unsatd. lactone, followed by, in the case of compds. I (R = CH:CH2, CBr:CH2), elimination reactions of a dibromo-compd. .

Studies on sialic acids

Studies on sialic acids. XXV. Synthesis of the a- and b-N-glycosides of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN).In this study， 140665-02-7 and 7288-28-0 are also used. Nakamura, Mitsunobu; Furuhata, Kimio; Yamasaki, Toshiko; Ogura, Haruo (Sch. Pharm. Sci., Kitasato Univ., Tokyo 108, Japan). Chem. Pharm. Bull., 39(12), 3140-4 (English) 1991. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Several a- and b-N-glycosides of title KDN (I) were synthesized under Vorbrueggen and Williamson reaction conditions. Two hexa-O-acetyl derivs. of I were treated with trimethylsilyl derivs. of pyrimidine, 5-fluoropyrimidine, and 5-methylpyrimidine, and azidotrimethylsilane to give mixts. of a- and b-N-glycoside derivs. of I. Two penta-O-acetyl-2-chloro derivs. of I were treated with the sodium salts of 2,4(1H,3H)-pyrimidinedione, 5-fluoro-2,4(1H,3H)-pyrimidinedione, and 5-methyl-2,4(1H,3H)-pyrimidinedione to give only the a-N-glycosides. The anomeric configurations of these compds. could be elucidated on the basis of the coupling pattern of C-1 in 13C NMR spectral anal. .