Reference

The carcinogen ethionine elevates progesterone levels

The carcinogen ethionine elevates progesterone levels. Sharma, Opendra K.; Borek, Ernest (Med. Cent., Univ. Colorado, Denver, Colo. 63596-32-7 is the cas registry number. This chemical is also mentioned in this article., USA). Nature (London), 265(5596), 748-9 (English) 1977. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In immature chicks pretreated for 10 days with estrogen, treatment with L-ethionine [13073-35-3] (0.25 mg/g, i.p.) plus adenine [73-24-5] (0.12 mg/g, i.p.) for 5 days increased serum progesterone [57-83-0] levels >10-fold. Total serum cholesterol [57-88-5] levels were also increased, but 17.beta.-estradiol [50-28-2] levels were unaffected. Ovalbumin formation by oviducts of estrogen-primed immature chicks was also increased by ethionine or L-ethionine sulfoxide [63640-45-9] but not by ethionine analogs. The ethionine-induced changes in serum progesterone may account for the changes in immature oviduct. .

Studies on the effect of various purine and pyrimidine derivatives on pyrimidine synthesis in humans

Studies on the effect of various purine and pyrimidine derivatives on pyrimidine synthesis in humans. Rauch-Janssen, A.; Groebner, W.; Zoellner, N. (Med. Poliklin., Univ. Muenchen, Munich, Ger.). Verh. Dtsch. Ges. Inn. Med., 82(1), 902-4 (German) 1976. CODEN: VDGIA2. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The administration of allopurinol [315-30-0] to healthy subjects on a purine-free diet led to a sharp increase in the formation and urinary excretion of orotic acid (I) [65-86-1], but this pyrimidine synthesis was diminished by addn. of AMP [61-19-8], uridine [58-96-8], or hypoxanthine [68-94-0] to the diet. IMP [131-99-7], xanthine [69-89-6], guanine [73-40-5], uracil [66-22-8], and adenine [73-24-5] had lttle or no effect on the allopurinol-induced orotic aciduria.