Detail of "7304-32-7"

CAS Number:
7304-32-7
Name:
Benzoicacid, 2-fluoro-5-nitro-
Superlist Name:
2-Fluoro-5-nitrobenzoic acid
Molecular Structure:
Formula:
C₇H₄FNO₄
Molecular Weight:
185.11
Synonyms:
NSC 133450;
Density:
1.568 g/cm³
Melting Point:
142-144 °C(lit.)
Boiling Point:
337.7 °C at 760 mmHg
Flash Point:
158 °C
Appearance:
white to light yellow crystal powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

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Reference

Preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors: Preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors. Gill, Adrian Liam; Woodhead, Steven John; Woodhead, Andrew James; Frederickson, Martyn; Padova, Alessandro; Apaya, Robert Patrick (Astex Technology Limited, UK). PCT Int. Appl. WO 2005002673 A1 13 Jan 2005, 143 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR.Chemicals with cas numbers 7304-32-7 and 642085-49-2 also play role. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61P035-00. ICS: A61K031-4412; A61K031-4965. APPLICATION: WO 2004-GB2877 2 Jul 2004. PRIORITY: US 2003-2003/PV48430U 3 Jul 2003; US 2003-2003/PV484300 3 Jul 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. I [X=Y = CR2=CR3, CR2=N; R1 = H, halo, amino, etc.; R2-3 = H, alkyl, aryl, etc.; R4 = carboaryl, heteroaryl, etc.; R5 = halo, amino, etc.] are prepd. For instance, 2-amino-3-benzyloxypyridine is prepd. from 2-amino-3-hydroxypyridine and benzyl chloride. Over 180 examples are provided. Selected example compds. have an IC50 < 1 mM for B-Raf kinase. I are useful in the treatment of a condition ameliorated by the inhibition of raf kinase, e.g., cancer. .

Preparation of N-substituted 5-nitroanthranilic acids for treating brain edema: Preparation of N-substituted 5-nitroanthranilic acids for treating brain edema. Englert, Heinrich C.; Greger, Rainer; Hropot, Max; Lang, Hans Jochen (Hoechst A.-G. , Fed. Rep. 134-20-3 and 7304-32-7 are cas registry numbers. These chemicals are also mentioned in this article. Ger.). Ger. Offen. DE 3528048 A1 5 Feb 1987, 6 pp. (Germany) CODEN: GWXXBX. CLASS: ICM: C07C101-52. ICS: C07D307-52; A61K031-19; A61K031-34; A61K031-395. APPLICATION: DE 85-3528048 5 Aug 1985. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 1 The title compds. I [R = H, C1-4 alkyl; Z = (substituted) alkylene; Ar = (substituted) aryl or heteroaryl], useful for treating brain edema (no data), are prepd. A dimethylacetamide soln. contg. 15.3 g 2-chloro-5-nitrobenzoic acid and 49.3 g 3-phenylpropylamine was heated at 145° for 2 h to give I [R = H, Z = (CH2)3, Ar = Ph]. .

Detail of "7304-32-7"

Benzoicacid, 2-fluoro-5-nitro-

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CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

CAS No.7304-32-7 2-Fluoro-5-nitrobenzoic acid

Reference