Reference

Synthetic ion-exchange resins in quantitative analysis of pharmaceutical preparations

Synthetic ion-exchange resins in quantitative analysis of pharmaceutical preparations. XII. Complexometric determination of organic bases in different pharmaceutical forms. Jarzebinski, Jerzy; Jasinska, Elzbieta (Inst. Drug Sci., Sch. Med., Warsaw, Pol.). Acta Pol. Pharm., 33(4), 499-504 (Polish) 1976. CODEN: APPHAX. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Solns. contg. the drugs to be assayed were passed through columns packed with Amberlite IR-20 satd. with Zn2+ or Mg2+ and the cations were detd. in the eluate by titrn. with edetic acid. 142-88-1 and 147-24-0 are just another two chemicals used in this study. Consistent results are reported for piperazine adipate [142-88-1], benactyzine-HCl [57-37-4], diphenhydramine-HCl [147-24-0], bisacodyl [603-50-9], dihydralazine sulfate [7327-87-9], diprophylline [479-18-5], acetazolamide [59-66-5], procainamide-HCl [614-39-1], naphazoline-HCl [550-99-2], tripelennamine-HCl [22306-05-4], and thiamin-HCl [67-03-8]. .

Dihydralazine sulfate analysis using 2-methyl-3-nitropyridine-6-carboxaldehyde

Dihydralazine sulfate analysis using 2-methyl-3-nitropyridine-6-carboxaldehyde. Youssef, A. F.; Ibrahim, S. A.; Elshabouri, S. R. (Fac. Pharm., Univ. Assiut, Assiut, Egypt). J. Pharm. Sci., 66(1), 116-18 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A sensitive, selective colorimetric assay was developed for the quant. anal. of dihydralazine sulfate (I) [7327-87-9]. The method is based on the interaction of buffered (pH 4) I with a methanolic soln. of 2-methyl-3-nitropyridine-6-carboxaldehyde [25033-74-3] upon heating to give an orange color. This color can be quantified spectrophotometrically at 450 nm, with a lower limit of detection of 1 .mu.g/ml. The color is stable for at least 24 h. There is no interference from other drugs likely to be present along with I and common excipients. The method was used successfully for the detn. of I in combination with other drugs in different com. tablets. The developed method was applicable as a stability-indicating assay.