Reference

Preparation of N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide(Roxatid ine acetate)

Preparation of N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)acetoxyacetamide(Roxatid ine acetate). Lee, Byeong Seok; Yoo, Ji Sang (Kyung Dong Pharm. Co., Ltd., S.Some commonly used reagents like 73278-98-5 and 13831-30-6 are used in this experiment. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2003025394 A 29 Mar 2003, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07D211-18. APPLICATION: KR 2001-58257 20 Sep 2001. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Provided is a method of making Roxatidine acetate, N-(3-(3-(1-piperidinylmethyl)- phenoxy)propyl)acetoxyacetamide(represented by formula 1), a H2 receptor antagonist, which is a strong anti-ulcer agent. The method is economical because one pot synthesis and mild condition are employed to produce a high yield product. The method of synthesis of Roxatidin, N-(3-(3-(1-piperidinylmethyl)- phenoxy)propyl)acetoxyacetamide(represented by formula 1) characteristically comprises making anhyd. acetoxy acetic acid from hydroxy acetic acid and adding 3-(3-(1 piperidinylmethyl)phenoxy)propylamine in one pot reaction. .

Formamidines

Formamidines.Some chemicals with cas registry numbers like 100997-26-0 are also used. Foguet Ambros, Rafael; Anglada Burniol, Luis; Ortiz Hernandez, Jose A.; Sacristan Munoz, Aurelio; Castello Barenys, Jose M. (Ferrer Internacional S. A., Spain). Span. ES 531764 A1 1 Jul 1985, 24 pp. (Spain) CODEN: SPXXAD. CLASS: ICM: C07C123-00. APPLICATION: ES 84-531764 18 Apr 1984. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 1, 27, 28 R1NHCH:NSO2R2 [R1 = (furfurylthio)ethyl, (thiazolylmethylthio)ethyl, (imidazolylmethylthio)ethyl, [(piperidinomethyl)phenoxy]propyl; R2 = alkyl, Ph, alkyl-, halo-, or nitrophenyl], which were prepd., showed gastric secretion inhibitory activity comparable to that of cimetidine. Thus, 4-MeC6H4SO2N:CHOEt was treated with a 2-aminoethyl 4-thiazolylmethyl sulfide deriv. and KOH to give amidine I. .