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CAS No.: | 73404-00-9 |
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Name: | alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-phenylphenethyl alcohol |
Molecular Structure: | |
Formula: | C26H31 N O2 |
Molecular Weight: | 389.538 |
Synonyms: | Ethanol,1-[p-[2-(diethylamino)ethoxy]phenyl]-1,2-diphenyl- (6CI,7CI) |
Density: | 1.087g/cm3 |
Boiling Point: | 512.6°C at 760 mmHg |
Flash Point: | 263.8°C |
PSA: | 32.70000 |
LogP: | 4.88580 |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
Conditions | Yield |
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With sulfuric acid In dichloromethane at 0 - 20℃; for 1h; | 100% |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
clomiphene citrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid / dichloromethane / 1 h / 0 - 20 °C 2.1: N-chloro-succinimide / dichloromethane / 32 h / 20 °C 2.2: 0.5 h / 20 °C / pH 8 - 9 3.1: methanol / 2 h / 20 °C 4.1: ammonia / ethyl acetate 4.2: 1 h / 20 °C View Scheme |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
A
clomiphene
B
Zuclomiphene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / ethanol / 3 h / 50 °C / Reflux 2.1: N-chloro-succinimide / dichloromethane / 20 h / 20 °C 2.2: 0.5 h / 20 °C View Scheme |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 50℃; for 3h; Reflux; |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
clomiphene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid / dichloromethane / 1 h / 0 - 20 °C 2.1: N-chloro-succinimide / dichloromethane / 32 h / 20 °C 2.2: 0.5 h / 20 °C / pH 8 - 9 View Scheme |
1-{4-[2-(diethylamino)ethoxy]phenyl}-1,2-diphenylethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / dichloromethane / 1 h / 0 - 20 °C 2.1: N-chloro-succinimide / dichloromethane / 32 h / 20 °C 2.2: 0.5 h / 20 °C / pH 8 - 9 3.1: methanol / 2 h / 20 °C View Scheme |