Reference

N'-Substituted derivatives of N,N-diphenylhydrazine

N'-Substituted derivatives of N,N-diphenylhydrazine. III. Bar, Denise; Marcincal-Lefebvre, Annie (Lab.In this study， 107-99-3 and 7357-67-7 are also used. Chim. Org., Fac. Pharm. Lille, Lille, Fr.). Bull. Soc. Chim. Fr., (7-8, Pt. 2), 1207-10 (French) 1976. CODEN: BSCFAS. DOCUMENT TYPE: Journal CA Section: 25 (Noncondensed Aromatic Compounds) Section cross-reference(s): 23 Acylation of Ph2NNH2 (I) gave Ph2NNHCO(CH2)nCl (n = 1, 2) which reacted with Me2NH, Et2NH, pyrrolidine, piperidine, and morpholine to yield the resp. Ph2NNHCO(CH2)nNR2 (II). Hydride redn. of II gave the resp. Ph2NNH(CH2)n+1NR2 which were also prepn. by the reaction of I with Cl(CH2)n+1NR2. .

A process of manufacturing gefitinib via rearrangement of iminoquinazoline derivative

A process of manufacturing gefitinib via rearrangement of iminoquinazoline derivative. Gilday, John Peter; Welham, Matthew James (Astrazeneca AB; Astrazeneca UK Limited, Swed.). PCT Int. Appl. WO 2005023783 A1 17 Mar 2005, 29 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English).There are some reagents like 7357-67-7 is used in this study. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D239-94. APPLICATION: WO 2004-GB3720 1 Sep 2004. PRIORITY: GB 2003-20793 5 Sep 2003. 7357-67-7 is also in the experiment. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 45 The invention relates to an improved process for manuf. of gefitinib (I) via rearrangement reaction of quinazoline deriv. II. Gefitinib was prepd. via heterocyclization of N,N'-bis-(3-chloro-4-fluorophenyl)formamidine and 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile and subsequent rearrangement of the obtained iminoquinazoline deriv. II. ..