Detail of "739-71-9"

CAS Number:
739-71-9
Name:
5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N,b-trimethyl-
Molecular Structure:
Formula:
C20H26 N2
Molecular Weight:
294.48
Synonyms:
5H-Dibenz[b,f]azepine,5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro- (6CI,7CI,8CI); (?à)-Trimipramine;10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz[b,f]azepine; 5-(g-Dimethylamino-b-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine;5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 7162RP; IL 6001; RP 7162; Rhotrimine; Sapilent; Surmontil; Trimeprimine;Trimeproprimine; Trimipramine; b-Methylimipramine
Safety:
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: unspecified heart effects. When heated to decomposition it emits toxic fumes of NO_x. Details

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Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection: Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection. Suckow, Raymond F.; Cooper, Thomas B. (Anal. Psychopharmacol. Lab., Nathan S. Kline Inst. Psychiatr. Res., Orangeburg, NY 10962, USA). J. Pharm. Sci., 73(12), 1745-8 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A procedure for the detn. of trimipramine (I) [739-71-9], the demethyl [2293-21-2], 2-hydroxy [2064-15-5], and the 2-hydroxy demethyl metabolite [2064-14-4] in plasma by liq. chromatog. with electrochem. detection is described. A 1-mL plasma sample is made alk. with a carbonate buffer (pH 9.8) and extd. with 20% Et acetate in n-heptane. After back-extn. into an acid phosphate buffer, an aliquot is injected onto a reverse-phase trimethylsilyl-packed column and eluted with a phosphate buffer-acetonitrile mobile phase () contg. n-butylamine. The peaks were detected at + 1.1 V vs. the Ag-AgCl ref. electrode. The method provides abs. recoveries of 60-91% and a day-to-day precision of <9% for all compds. The min. quantifiable level for all compds. was 3 ng/mL. Steady-state plasma concn. data for 29 depressed patients receiving either 75 mg or 150 mg/day is reported.

Anticholinergic effect of neuroleptics and antidepressants on the guinea pig ileum: Anticholinergic effect of neuroleptics and antidepressants on the guinea pig ileum. Comparison with atropine and pirenzepine. Alvarez Gonzalez, F. Javier; Garcia-Pando, Alfonso Carvajal; Casas Gonzalez, Maria Teresa; Martinez de Zarate, J. Luis Gonzalez; Velasco Martin, Alfonso (Dep. Pharmacol. Ther., Fac. Med., Valladolid, Spain). J. Pharmacol., 15(2), 177-84 (French) 1984. CODEN: JNPHAG. ISSN: 0021-793X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) All the neuroleptics and antidepressants tested showed anticholinergic activity in the guinea pig ileum stimulated either elec. or with exogenous acetylcholine. The relative order of potency was: atropine [51-55-8] > pirenzepine [28797-61-7] > trimipramine [739-71-9] > clozapine [5786-21-0] > clotiapine [2058-52-8] > thiothixene [5591-45-7] > trazodone [19794-93-5]. Atropine, pirenzepine, and trazodone were competitive antagonists, while the remaining drugs showed noncompetitive antagonism. For most of the compds., the action was at the postsynaptic levels. No relation was obsd. between anticholinergic activity and extrapyramidal effects of the neuroleptics, or between anticholinergic and antidepressant activities.