Detail of "7390-81-0"

Reference

Comparative mutagenicity of aliphatic epoxides in Salmonella

Comparative mutagenicity of aliphatic epoxides in Salmonella. Canter, Dorothy A.; Zeiger, Errol; Haworth, Steve; Lawlor, Timothy; Mortelmans, Kristien; Speck, William (Natl. Inst. Environ. Health Sci., Bethesda, MD, USA). Mutat. Res., 172(2), 105-38 (English) 1986. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Thirty-seven aliph. epoxides comprising 6 subclasses (unsubstituted aliph. epoxides, halogenated aliph. epoxides, glycidyl esters, glycidates, glycidyl ethers and diglycidyl ethers) were tested, under code, for mutagenicity in Salmonella strains TA98, TA100, TA1535 and TA1537 and(or) TA97 with and without metabolic activation using a standardized protocol. The 4 halogenated aliph. 930-37-0 and 7390-81-0 which are cas registry numbers are also used here. epoxides and the 4 diglycidyl ethers were all mutagenic. The 2 glycidates were neg. in all strain/activation systems used whereas all 5 glycidyl esters were mutagenic. Three of 8 unsubstituted aliph. epoxides and 11 of 12 glycidyl ethers were mutagenic. Glycidol (I) [556-52-5] also was mutagenic whereas 9,10-epoxyoctadecanoic acid 2-ethylhexyl ester [141-38-8] was not mutagenic. Of the 28 mutagenic compds., all but neodecanoic acid 2,3-epoxypropyl ester [26761-45-5] and 2-ethylhexyl glycidyl ether [2461-15-6] were detected in TA100 without activation. The latter 2 were detected only with activation in TA100 and TA1535. The majority of the other 26 chem. were also mutagenic in TA1535 without activation. Good intra- and interlab. reproducibility was seen in the results of each of the 4 chem. tested in >1 set of expts. The current results confirm and extend the observations of other investigators regarding structural effects on the mutagenicity of members of the aliph. epoxide class of chem. .

process for the preparation of (2-hydroxyalkyl)-substituted b-dicarbonyl compounds from oxiranes and dicarbonyl compounds

process for the preparation of (2-hydroxyalkyl)-substituted b-dicarbonyl compounds from oxiranes and dicarbonyl compounds. Stoll, Gerhard; Klamann, Joerg Dieter; Renga, James (Henkel K.-G.a.A., Germany). Ger. Offen. DE 4024065 A1 30 Jan 1992, 4 pp. (Germany). CODEN: GWXXBX. CLASS: ICM: C07C049-17. ICS: C07C069-675; C07C049-172; C07C045-64. ICA: C07C043-11. APPLICATION: DE 90-4024065 27 Jul 1990. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) A process for the prepn. of (2-hydroxyalkyl)-substituted b-dicarbonyl compds. comprises the treatment of R1COC2COR2 (R1, R2 = alkyl, aryl, acryl) with an epoxide in the presence of polyalkylene glycol ethers and/or base. The oxirane ring is opened by nucleophilic attack by the dicarbonyl compd. either via a primary or secondary carbanion. The presence of a solvent is not required. The products are not readily flammable. A reactor was charged with 1,2-epoxydodecane (184.3 g), 2,4-pentanedione (150.2 g), and Et3N (1.5 g) and heated to 150° for 12 h. The product thus obtained had an epoxide oxygen content of 0.6% by wt. 2855-19-8 and 7390-81-0 are just another two chemicals used in this study. and a flash point of 173° (DIN 51 758). .