CAS No.74-94-2,Dimethylaminoborane Suppliers

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Basic Information

Molecular Structure:
CAS No.:	74-94-2
Name:	Dimethylaminoborane
Article Data:	42

Formula:	C₂H₁₀BN
Molecular Weight:	58.9191
Synonyms:	Dimethylamine,compd. with BH3 (6CI);Dimethylamine, compd. with borane (1:1) (8CI);Methanamine, N-methyl-, compd. with borane (1:1);Borane, compd. withN-methylmethanamine (1:1);Borane, compd. with dimethylamine (1:1) (8CI);Methanamine, N-methyl-, boron complex;(Dimethylamine)trihydroboron;Dimethylamine compound with borane (1:1);Dimethylamine-borane;NSC 10218;Boron,trihydro(N-methylmethanamine)-, (T-4)-;
EINECS:	200-823-7
Density:	0.69 g/cm³
Melting Point:	36 °C(lit.)
Boiling Point:	59-65 °C
Flash Point:	65 °C
Solubility:	125 g/L in water at 20°C
Appearance:	white crystalline powder with an amine odour
Hazard Symbols:	F,T
Risk Codes:	11-24/25-36/37/38-20
Safety:	16-28-36/37-45-33-15
Transport Information:	UN 2926 4.1/PG 2
PSA:	23.85000
LogP:	-0.95740

Synthetic route

: 16940-66-2
sodium tetrahydroborate

dimethylammonium salt: dimethylammonium salt

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h;	93%

: 124-40-3
dimethyl amine

: 19287-45-7
diborane

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
In neat (no solvent) excess amine, 30-40°C, concn. of soln.;; distn. in vac. (60°C/2Torr) or recrystn. (petroleum ether);;	91%
In neat (no solvent) excess amine, 30-40°C, concn. of soln.;; distn. in vac. (60°C/2Torr) or recrystn. (petroleum ether);;	91%
In diethyl ether product in liquid form, crystn. on standing;; distn. in vac.;;	961 %
In gas determination of react.-enthalpy;;
for 2h; Inert atmosphere; Gas phase; Cooling with ice;

: 16940-66-2
sodium tetrahydroborate

: 124-40-3
dimethyl amine

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
With iodine In 1,2-dimethoxyethane byproducts: NaI, H2; dropwise addn. of NaBH4 and I2 in DME to amine in DME, removal of solvent, addn. of C6H6, filtration, evapn. of filtrate in a N2 stream, drying in vac.;; recrystn. from CH2Cl2/hexane mixture;;	84.4%
With potassium dihydrogenphosphate In water at -20 - 5℃; for 10h; Solvent; Reagent/catalyst; Autoclave; Large scale;	84.5%
With boron trifluoride diethyl etherate In tetrahydrofuran refluxing, filtartion, evapn. of solvent;;

: 506-59-2
N,N-dimethylammonium chloride

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
With sodium tetrahydroborate In 1,2-dimethoxyethane at 20℃; Cooling with ice;	71%
With lithium borohydride In diethyl ether at -78 - 20℃;

: lithium borohydride

: 506-59-2
N,N-dimethylammonium chloride

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
In neat (no solvent) in vac., 3h;; distn. in vac. at 75-76°C/0.5Torr;;	70%
In diethyl ether byproducts: H2, LiCl; room temp., 3h, filtration, evapn.;; recrystn. from C6H6/petroleum ether;;
In diethyl ether amine hydrochloride was added at -78°C to soln. LiBH4 in Et2O andstirred for 30 min, allowed to warm to room temp. and stirred for 5 h; react. mixt. was cooled to -45°C, slvent was removed in vacuo, residue was heated in vacuo at 65°C for sublimation;

: potassium borohydride

: 506-59-2
N,N-dimethylammonium chloride

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
With sodium hydroxide In 1,2-dimethoxyethane; water at -5 - 15℃; for 6 - 10h; Conversion of starting material;	55.1%
With sodium hydroxide In tetrahydrofuran; water at -10 - 15℃; for 10 - 14h; Conversion of starting material;	54%

: Me3N*BH2SPh

: 124-40-3
dimethyl amine

A: 74-94-2
dimethylamine borane

B: 1387442-05-8
Me2NH*BH2SPh

Conditions

Conditions	Yield
at 20℃; for 36h;	A 10% B 46%

...Expand

: 1838-13-7
dimethylamine borane

: lithium borohydride

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
In tetrahydrofuran; water at 20℃; for 4h; Inert atmosphere;	10%

: calcium borohydride

: 124-40-3
dimethyl amine

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
In tetrahydrofuran

: boron trioxide

: 1333-74-0
hydrogen

: 124-40-3
dimethyl amine

: 74-94-2
dimethylamine borane

Conditions

Conditions	Yield
With aluminium trichloride; aluminium In neat (no solvent) High Pressure; heating the mixture under a H2-pressure of 800-900kg/cm**2 to 273°C for 10h; in mixture with other products;;

...Expand

Raw Materials

124-40-3

74-89-5

593-57-7

Downstream Products

617-86-7

23273-02-1

10043-11-5

33905-38-3

688-73-3

150-46-9

124-40-3

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The Dimethylaminoborane, with the CAS registry number 74-94-2, is also known as Dimethylamine compound with borane (1:1). It belongs to the product categories of Organometallics; B (Classes of Boron Compounds); Boranes; Reduction; Synthetic Organic Chemistry; Organoboron and borato-metal complexes. Its EINECS number is 200-823-7. This chemical's molecular formula is C₂H₁₀BN and molecular weight is 58.92. What's more, its systematic name is Trihydrido(N-methylmethanamine)boron. Its classification codes are: (1)Drug / Therapeutic Agent; (2)Mutation data; (3)Skin / Eye Irritant. It should be sealed and stored in a cool and ventilated place. Moreover, it should be protected from oxides, heat and fire. It is sensitive to water and air. This chemical is used in reductivealkylation of protein.

Physical properties of Dimethylaminoborane are: (1)#H bond acceptors: 1; (2)#H bond donors: 0; (3)#Freely Rotating Bonds: 1; (4)Polar Surface Area: 4.44 Å².

When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable, so you should keep it away from sources of ignition - No smoking. It is toxic in contact with skin and if swallowed and is harmful by inhalation. After contact with skin, you must wash immediately with plenty of ... (to be specified by the manufacturer). This substance is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and gloves. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible). You need take precautionary measures against static discharges and keep this chemical away from heat.

You can still convert the following datas into molecular structure:
(1)SMILES: [BH3-][NH+](C)C
(2)Std. InChI: InChI=1S/C2H10BN/c1-4(2)3/h4H,1-3H3
(3)Std. InChIKey: RUOMFVPJBOADHA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	55900ug/kg (55.9mg/kg)		"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
guinea pig	LDLo	oral	50mg/kg (50mg/kg)		National Technical Information Service. Vol. OTS0535833.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		Journal of Pharmaceutical Sciences. Vol. 69, Pg. 1025, 1980.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05150.
mouse	LDLo	oral	50mg/kg (50mg/kg)		National Technical Information Service. Vol. OTS0535833.
rabbit	LD50	intraperitoneal	35100ug/kg (35.1mg/kg)		"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit	LD50	skin	210mg/kg (210mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	National Technical Information Service. Vol. OTS0535833.
rat	LD50	intraperitoneal	39mg/kg (39mg/kg)		"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rat	LD50	oral	59mg/kg (59mg/kg)		American Industrial Hygiene Association Quarterly. Vol. 16, Pg. 280, 1955.