Detail of "74014-51-0"

CAS Number:
74014-51-0
Name:
Leucomycin V,4B-butanoate 3B-propanoate
Molecular Structure:
Formula:
C42H69 N O15
Molecular Weight:
827.995
Synonyms:
Oxacyclohexadecane,leucomycin V deriv.; 3''-Propionylleucomycin A5; Ricamycin; Rokitamycin; TMS19Q
Density:
1.21 g/cm³
Boiling Point:
879.3 °C at 760 mmHg
Flash Point:
485.6 °C

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Metabolism of rokitamycin (TMS-19-Q), a new 16-membered macrolide antibiotic, and effects of its metabolites on plasma level as total activity: Metabolism of rokitamycin (TMS-19-Q), a new 16-membered macrolide antibiotic, and effects of its metabolites on plasma level as total activity. Suzuki, T.; Sakai, A.; Morishita, M. (Pharm. Res. Lab., Toyo Jozo Co., Ltd., Shizuoka, Japan). Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 2, 1427-8. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The metab. of rokitamycin (I) [74014-51-0] was studied in human, dogs, and rats. Rokitamycin was rapidly absorbed after oral administration and was biotransferred to the active metabolites. The main metabolic reactions of rokitamycin were deacylation and hydroxylation. 22875-15-6 and 94659-43-5 which are cas registry numbers of substances are two of reagents here. Relative potency of rokitamycin and the metabolites was calcd. from each std. curve in human plasma by 3 bioassay methods. The antibacterial activity in relation to metab. is discussed. .

Stabilization of macrolide antibiotics in oral formulations: Stabilization of macrolide antibiotics in oral formulations. (Toyo Jozo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59104326 A2 16 Jun 1984 Showa, 35 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K047-00. ICA: A61K031-71. APPLICATION: JP 82-212942 4 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Oral formulations contain 16-member ring antibiotic macrolides stabilized by one or more stabilizers at pH 3~10. The stabilizers are glycine [56-40-6], glycine aluminum salt [52729-29-0], L-alanine [56-41-7], monosodium glutamate [142-47-2], monosodium aspartate [3792-50-5], etc. Thus, granules consisting of 3''-propionylleucomycin A5 [74014-51-0] 105.3, anhyd. silicic acid 30.0, and hydroxypropyl Me cellulose 7 g were mixed with other granules consisting of glycine 170, citric acid 0~40, anhyd. silicic acid 10, and hydroxypropyl Me cellulose 5 g. To this mixt. were added hydroxypropyl cellulose, Avicel PH-301, and Mg stearate. The mixt. was made into tablets (430 mg/tablet).