Detail of "74103-07-4"

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CAS Number:
74103-07-4
Name:
Ketorolac tris salt
Molecular Structure:
Formula:
C₁₅H₁₃NO₃
Molecular Weight:
376.40
Synonyms:
Ketorolac Tromethamine;RS 37619;Ketorolac Trometamol;
Melting Point:
160-161 °C
Boiling Point:
493.2 °C at 760 mmHg
Flash Point:
252.1 °C
Hazard Symbols:
T
Risk Codes:
25-36/37/38-23/24/25
Safety:
26-45-36/37/39 Details
Transport Information:
UN 2811 6.1/PG 3

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Reference

In vitro rabbit corneal permeability study of ketorolac tromethamine, a non-steroidal anti-inflammatory agent: In vitro rabbit corneal permeability study of ketorolac tromethamine, a non-steroidal anti-inflammatory agent. Fu, Roger Cherng Chyi; Lidgate, Deborah M. (Inst. Pharm. Sci., Syntex Res., Palo Alto, CA 94304, USA). Drug Dev. Ind. Pharm., 12(14), 2403-30 (English) 1986. CODEN: DDIPD8. ISSN: 0363-9045. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 In vitro, ketorolac tromethamine (I) [74103-07-4] shows a pH-dependent penetration of rabbit cornea; it also exhibits penetration in both the unionized as well as ionized forms. Results of preservative evaluation shows that benzalkonium chloride enhances penetration whereas thimerosal [54-64-8] has no effect. Evaluation of the counter ions paired with I gave penetration rates in the following descending, relative, order: quaternary ammonium compds. > guanidino compds. > aliph. amines > alkali metal.

Drug-excipient interactions resulting from powder mixing, II: possible mechanism of interaction with crospovidone and its effect on in vitro dissolution: Drug-excipient interactions resulting from powder mixing, II: possible mechanism of interaction with crospovidone and its effect on in vitro dissolution. Chowhan, Zak T.; Chi, Li Hua (Inst. Pharm. Sci., Syntex Res., Palo Alto, CA, USA). Pharm. Technol., 9(4), 28, 30, 32-3, 36, 38-41 (English) 1985. CODEN: PTECDN. ISSN: 0147-8087. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Two powder mixts., contg. H2O sol. ketorolac tromethamine (I) [74103-07-4] of different particle sizes and crospovidone (II) [9003-39-8], lactose [63-42-3], and Mg stearate [557-04-0] as excipients, were investigated for interaction between drug and excipient particles and their effects on dissoln. rate. The smaller drug particles showed the greater dissoln. rate as a result of adhesion to the surfaces of II making them readily accessible for dissoln. The larger particles were entrapped into the void spaces of II agglomerates, resulting in lower drug recovery during dissoln. testing. After Mg stearate was added, the disintegration time was increased, and dissoln. rate decreased. Mixing caused Mg stearate to flake, the flakes adhering to the surface of the I-II agglomerates which decreased drug dissoln. More flaking was obsd. in the mixt. with smaller drug particles as a result of increased interaction between the larger no. of drug particles and the excipient particles in the powder mixt. Thus, the drug dissoln. rate was slower for the mixt. with smaller drug particles.

Detail of "74103-07-4"

Ketorolac tris salt

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Reference