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Detail of "7414-83-7"

  • CAS Number:
  • 7414-83-7
  • Name:

  • Phosphonicacid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)

  • Superlist Name:
  • Etidronate disodium
  • Molecular Structure:
  • Formula:
  • C2H6Na2O7P2
  • Molecular Weight:
  • 249.99
  • Deleted CAS:
  • 187285-10-5
  • Synonyms:
  • Phosphonicacid, (1-hydroxyethylidene)bis-, disodium salt (9CI);1-Hydroxyethane-1,1-diphosphonicacid disodium salt;BA 49280E;Calcimux;Chelest PH 212;Didronel;Didronel R;Disodium (1-hydroxyethylidene)-1,1-bisphosphonate;Disodium 1-hydroxyethane-1-diphosphonate;Disodium 1-hydroxyethanediphosphonate;Disodium1-hydroxyethylidenediphosphonate;Disodium ethane-1-hydroxy-1,1-diphosphonic acid;Disodiumethane-1-hydroxy-1-diphosphonate;Disodiumethydronate;Etidron;Etidronate disodium;Etidronic aciddisodium salt;Fostex NZ 2;Ostedron;Sequion 10Na2;Sodiumethane-1-hydroxy-1,1-diphosphonate;Sodium ethidronate;Sodium ethydronate;TF 133B (chelating agent);Turpinal 2NZ;Xydifon;HEDP.Na2;
  • EINECS:
  • 231-025-7
  • Boiling Point:
  • 578.8 °C at 760 mmHg
  • Flash Point:
  • 303.8 °C
  • Solubility:
  • 26 mg/mL in water
  • Appearance:
  • white crystalline powder
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 22
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CAS No.7414-83-7 Etidronate disodiumCompetitive Product

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CAS No.7414-83-7 Etidronate disodium

Assay:99.0%  Appearance:A white or y...  Package:1kg with Alu...Storage:store in coo...  Application:osteoporosis

CAS: 7414-83-7 Name: Etidronate disodium Synonyms: Sodium etidronate; Etidronic acid disodium salt; ( 1-Hydroxyethane-1, 1-diyl) diphosphonic acid disodium salt Molecular Formula: C2H6Na2O7P2 Molecular Weight: 249.99 Action: osteoporosis Quality Standard: USP31; BP2

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Reference

Toxicological study of the noncyanide electroplating complexing agent disodium etidronate
Toxicological study of the noncyanide electroplating complexing agent disodium etidronate. Chen, Jie; Yang, Mingding (Dep. Environ. Health, Shanghai First Med. Coll., Shanghai, Peop. Rep. China). Shanghai Diyi Yixueyuan Xuebao, 10(6), 447-52 (Chinese) 1983. CODEN: SIIPD4. ISSN: 0253-3650. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The absorption rate of 99mTc-labeled disodium etidronate (DE) [7414-83-7] in mice within 24 h after oral administration was ~20%. Most of the DE absorbed was concd. in hard tissue, only a small fraction was distributed in other organs. The biol. half-time of 99mTc-DE was 13.75 h. Thus, 2.86 day was required to excrete 95% of the oral dose of DE. Therefore, a slight accumulation would occur when successive doses were given at intervals of <24 h. The oral LD50 of DE was ~2.05 g/kg in mice and 1.69 g/kg in rats, implying a low toxicity. After prolonged oral administration with a larger dose of DE, the rats developed metabolic disturbances of Ca and phosphate. The histopathol. and roentgenol. findings were similar to those of rachitis, and the growth and development of the bone and dental matrix were delayed or retarded. Thus, the threshold dose of DE causing chronic intoxication was 160 mg/kg/day, and the safety subthreshold dose 40 mg/kg/day.
Radiographic indicator (scanning agent)
Radiographic indicator (scanning agent). Tofe, Andrew J. (Procter and Gamble Co., USA). Ger. Offen. DE 2618337 11 Nov 1976, 27 pp. 5743-27-1 and 39478-93-8 are cas registry numbers. These chemicals are also mentioned in this article. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K029-00. PRIORITY: US 75-573220 30 Apr 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 8 Stable solns. of 99TcmO4- for bone scintigraphy contain Sn2+, Fe2+, or Cr2+ as reducing agent, ascorbic acid (I) [50-81-7] or a deriv. thereof as stabilizer, and a mono-, di-, or polyphosphate as skeletal-sp. carier. Thus, mixing 0.1 mg Na ascorbate [134-03-2], 5 mL 99TcmO4- soln., 5.9 mg di-Na ethane-1-hydroxy-1,1-diphosphonate [7414-83-7], and 0.16 mg SnCl2 gave an indicator stable for >3 h and suitable for i.v. injection. .
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