Detail of "74176-31-1"

Reference

Induction of parturition in swine with a prostaglandin analog and oxytocin: a trial involving dose of oxytocin and parity

Induction of parturition in swine with a prostaglandin analog and oxytocin: a trial involving dose of oxytocin and parity. Welp, C.; Joechle, W.; Holtz, W. (Inst. Tierzucht Haustiergenet., Univ. Goettingen, Goettingen, Fed. Rep. Ger.). Theriogenology, 22(5), 509-20 (English) 1984. CODEN: THGNBO. ISSN: 0093-691X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The purpose of this expt. was to compare a range of oxytocin [50-56-6] doses in order to find the most suitable dose to improve predictability and precision of timing of Alfaprostol [74176-31-1]-induced parturition in sows. Sows randomly allotted to 6 groups-group size varying between 28 and 39-were either untreated controls (group 1) or received an i.m. injection of 2 mg of Alfaprostol on day 111 of pregnancy (day 0 = last day of standing heat), followed 20 h later by 0, 5, 10, 20, or 30 IU oxytocin, resp. (groups 2-6). Both length and variability of the time from injection of oxytocin to the onset of parturition decreased with increasing dose. The response was faster and more predictable with older sows than with 1st litter gilts. A disadvantage of higher doses of oxytocin was the necessity of manual aid (11% in controls, 52% with the max. level of 30 IU oxytocin). Litter size, wt., and percentage of piglets weaned and time from weaning to subsequent estrus were not affected by any of the treatments. An oxytocin dose of 20 IU applied 20 h after Alfaprostol appeared to give the most effective response, although this will occasionally necessitate manual assistance with parturition.

Absorption, distribution, and excretion of alfaprostol-14C in cows, horses, and pigs

Absorption, distribution, and excretion of alfaprostol-14C in cows, horses, and pigs. Jeffcoat, A. R.; Wani, M. C.; Mraz, F. M.; Ballabio, R. (Res. Triangle Inst., NC, USA). Riv. Zootec. Vet., 12(1), 45-9 (Italian) 1984. CODEN: RZOVBM. ISSN: 0304-0607. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 17 Following i.m. injection of 14C-labeled alfaprostol (I) [74176-31-1] into cows, horses, and pigs, the substance or its metabolites were rapidly excreted in the urine and feces; <1 ng/kg tissue was found in the muscle and large intestine 30 min after administration. No accumulation in tissues or organs was obsd., and <0.1% of the dose was excreted in 5 days in bovine milk. Calcns. based on residue detns. and on toxicity data from the literature showed that suspension of I treatment 24 h before slaughter is sufficient to avoid any risk to consumers of the meat and milk.