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Detail of "74811-65-7"

  • CAS Number:
  • 74811-65-7
  • Name:

  • Croscarmellose sodium

  • Molecular Weight:
  • 0
  • Synonyms:
  • AcDiSol;Croscarmellose; Explocel; Kiccolate; Kiccolate ND 200; Kiccolate ND 2HS; NymcelZSX; Pharmacel XL; Primellose; Sodium Croscarmellose; Vivasol
  • Appearance:
  • Free-flowing, fibrous powder
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CAS No.74811-65-7 Croscarmellose sodium

  Appearance:A White free...  Package:5kg/bag

Product: Croscarmellose Sodium Batch No. 110103 MFG DATE JAN.22,2011 Tests Standard USP Results Identification A,B,C Positive Conforms PH 5.0-7.0 5.9 Loss on Drying % Not more than 10.0 2.7 Na-chloride&Na-glycolate % No

Min. Order:1 FCLMetric Ton USD:1500-3200 /Metric Ton

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CAS No.74811-65-7 Croscarmellose sodium

The cross-linking reduces water solubility while still allowing the material to swell (like a sponge) and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas' subsequent bioavailabil

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CAS No.74811-65-7 Croscarmellose sodium

Croscarmellose Sodium, NF

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

Tablet disintegrant Appearance:Free-flowing, fibrous powder

Supplier:quest [ Netherlands]

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CAS No.74811-65-7 Croscarmellose sodium

Tablet disintegrant Appearance:Free-flowing, fibrous powder

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CAS No.74811-65-7 Croscarmellose sodium

Tablet disintegrant Appearance:Free-flowing, fibrous powder

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CAS No.74811-65-7 Croscarmellose sodium

Tablet disintegrant Appearance:Free-flowing, fibrous powder

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CAS No.74811-65-7 Croscarmellose sodium

Tablet disintegrant Appearance:Free-flowing, fibrous powder

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CAS No.74811-65-7 CROSCARMELLOSE SODIUM

CROSCARMELLOSE SODIUM

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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CAS No.74811-65-7 Croscarmellose sodium

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Reference

A thermodynamic study of the Ac-Di-Sol-water and CLD-2-water surface interaction
A thermodynamic study of the Ac-Di-Sol-water and CLD-2-water surface interaction. Gordon, R. E.; Peck, G. E.; Kildsig, D. O. (Sch. Pharm. Pharm. Sci., Purdue Univ., West Lafayette, IN 47907, USA). Drug Dev. Ind. Pharm., 10(6), 833-60 (English) 1984. CODEN: DDIPD8. ISSN: 0363-9045. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Absorption-desorption studies and immersional calorimetry were used conjointly to characterize the surface properties of 2 disintegrants-Ac-Di-Sol [74811-65-7] and CLD-2 [76632-87-6]. Adsorption-desorption isotherms were utilized to calc. the integral and different Gibb's free energies. Nonisothermal calorimetry was employed to quantify the energies of interaction between the adsorbate and the adsorbent and obtain the differential enthalpy. These interactions were detd. to be -7.5 and -7.8 kcal/mol for Ac-Di-Sol and CLD-2, resp. The premature decrease in the differential enthalpies and entropies and the obsd. immersional and adsorption-desorption hystereses were hypothesized to be the result of an irreversible swelling process. Differences were obsd. between CLD-2 and Ac-Ci-Sol which were believed to be due to the higher degree of crosslinking in Ac-Di-Sol.
Release of drugs formulated as hard pastes filled into hard gelatin capsules
Release of drugs formulated as hard pastes filled into hard gelatin capsules. Part 1. Physical properties and in vitro testing. Djimbo, M.; Moes, A. J. (Lab. Pharm. Galenique Biopharm., Univ. Bruxelles, Brussels 1050, Belg.). J. Pharm. Belg., 39(1), 36-42 (English) 1984. CODEN: JPBEAJ. ISSN: 0047-2166. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Various hard past formulations contg. 50% theophylline [58-55-9] or acetylsalicylic acid (ASA) [50-78-2] were prepd. and introduced into hard gelatin capsules. The excipients used were PEG [25322-68-3] blends, PEG-partial medium-chain glycerides mixt. and water-dispersible fats (Gelucire). The study of the rheol. properties of pastes has shown that all the formulations are highly pseudoplastic once the flow has begun, with the apparent viscosity increasing exponentially as the concn. of the dispersed solid phase increases. The in vitro dissoln. studies show that the ASA release from the dosage forms is rapid and complete when hydrosol. excipients like PEG are employed. The ASA release rate from the dosage forms prepd. with Gelucires is smaller and depends on the melting characteristics of the water-dispersible fats. For both types of formulations, the ASA release rate increases significantly when the drug/excipient ratio decreases. Finally, the addn. of powerful disintegrants into the dosage forms does not improve the ASA release very much except when high concns. are used (10% Ac-Di-Sol [74811-65-7]).
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