Detail of "74817-61-1"

Reference

Enhancement by murabutide of the immune response to natural and synthetic hepatitis B surface antigens

Enhancement by murabutide of the immune response to natural and synthetic hepatitis B surface antigens. Audibert, Francoise M.; Przewlocki, Grzegorz; Leclerc, Claude D.; Jolivet, Michel E.; Gras-Masse, Helene S.; Tartar, Andre L.; Chedid, Louis A. (Inst. Pasteur, Paris 75724, Fr.). Infect. Immun., 45(1), 261-6 (English) 1984. CODEN: INFIBR. ISSN: 0019-9567. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 15 The adjuvant-active , murabutide [74817-61-1], administered to mice with natural and synthetic hepatitis B surface antigens (HBsAgs), enhanced the antibody responses against natural HBsAg. The persistence of high antibody titers was the same in the murabutide-treated group as in the alum (Alugel 50 [91593-85-0])-treated group. A synergistic enhancement of the antibody was obtained when both adjuvants were administered together. Cell-mediated immunity to HBsAg, tested by the proliferative response of lymph node cells to the antigen, was also induced in mice treated with alum-assocd. murabutide. When administered with natural HBsAg, murabutide produced titers of total antibodies as high as did alum but lower titers of specific IgE. High levels of antipeptide antibodies were obtained when a synthetic fragment [HBsAg(99-121)] conjugated to a toxoid carrier was administered with murabutide in saline.

Comparison of immunomodulatory activities in mice and guinea pigs of a synthetic desmuramyl peptidolipid triglymyc

Comparison of immunomodulatory activities in mice and guinea pigs of a synthetic desmuramyl peptidolipid triglymyc. Leclerc, Claude D.; Audibert, Francoise M.; Chedid, Louis A. 73073-09-3 and 77411-39-3 are also occured in this study.; Deriaud, Edith J.; Masihi, Noel K.; Lededrer, Edgar (Inst. Pasteur, Paris, Fr.). Infect. Immun., 43(3), 870-5 (English) 1984. CODEN: INFIBR. ISSN: 0019-9567. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A nonpyrogenic desmuramyl peptidolipid 1-O-(L-alanyl-D-isoglutaminyl-L-alanyl-glycerol-mycolate)(triglymyc)(I) is capable of enhancing or suppressing the immune responses in mice when injected with or before an antigen. In vivo suppression of the immune response to sheep erythrocytes was also obsd. with high doses of murabutide [74817-61-1], a nonpyrogenic adjuvant-active N-acetylmuramyl-L-alanyl-D-isoglutamine analog. Chemiluminescence measurements with mouse spleen cells show a very strong activity of I by far superior to the effect obtained with the corresponding muramyl peptide N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanyl-glycerol-mycolate. .