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| CAS No.: | 7491-74-9 |
|---|---|
| Name: | Piracetam |
| Article Data: | 19 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H10N2O2 |
| Molecular Weight: | 142.158 |
| Synonyms: | Myocalm;Neuracetam;Nootobril;Nootobryl;Nootron;Nootrop;Nootropil;Nootropyl;Normabrain;Norzetam;(2-Oxopyrrolidino)acetamide;2-(2-Oxopyrrolidin-1-yl)acetamide;2-Ketopyrrolidine-1-acetamide;2-Oxo-1-pyrrolidineacetamide;2-Oxo-1-pyrrolidinylacetamide;2-Pyrrolidinoneacetamide;2-Pyrrolidoneacetamide;Avigilen;Axonyl;Cerebroforte;Cl 781;Encetrop;Euvifor;Gabacet;Genogris;Geram; |
| EINECS: | 231-312-7 |
| Density: | 1.239 g/cm3 |
| Melting Point: | 151-152 °C |
| Boiling Point: | 408.3 °C at 760 mmHg |
| Flash Point: | 200.8 °C |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-37/39 |
| PSA: | 63.40000 |
| LogP: | -0.26770 |
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- 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine
- 92884-66-7
N,N-Dimethyl-N'-(pyrrolidon-2-yl-1-acetyl)formamidine
A
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
B
- 61945-49-1
N,N-dimethyl-N'-homoveratrylformamidine
| Conditions | Yield |
|---|---|
| In benzene for 4h; Ambient temperature; | A 100% B n/a |
| In benzene for 4h; Ambient temperature; |
- 57275-83-9
nitrile of 2-oxopyrrolidine-1-acetic acid
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| With manganese(IV) oxide; water In isopropyl alcohol at 100℃; under 5171.62 Torr; for 0.25h; | 97% |
| With C34H38N6NiO2(2+)*2Cl(1-); water In isopropyl alcohol at 100℃; for 24h; Schlenk technique; Inert atmosphere; | 65% |
| With water; C34H38N6NiO2(2+)*2Cl(1-) In isopropyl alcohol at 100℃; for 24h; | 65% |
- 59776-88-4
methyl 2-oxo-1-pyrrolidineacetate
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| With ammonia In methanol at 60℃; for 4h; Sealed tube; | 93% |
| With ammonium hydroxide for 2h; | 78% |
| With ammonia In methanol at 60℃; for 4h; | 45.94% |
- 61516-73-2
2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| With ammonium hydroxide for 2h; | 91% |
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| Heating; | 75% |
| Conditions | Yield |
|---|---|
| With tert.-butylhydroperoxide; ammonium hydroxide In water at 100℃; for 16h; | 73% |
| Conditions | Yield |
|---|---|
| Stage #1: α-aminoacetamide hydrochloride In acetonitrile Inert atmosphere; Stage #2: 4-Chlorobutanoyl chloride With sodium hydroxide In acetonitrile at 0 - 5℃; for 3h; Reagent/catalyst; Solvent; Temperature; | 70% |
- 64026-51-3
2-(4-chlorobutyramido)acetamide
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| With sodium ethanolate In ethanol at 50℃; for 8h; | 45% |
- 142352-10-1
(2,4-dioxopyrrolidin-1-yl)acetamide hydrochloride
A
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
C
- 77191-37-8
4-hydroxy-2-oxo-1-pyrrolidine acetic acid
D
- 105240-61-7
3-(1-(carbamoylmethyl)-2-oxo-3-pyrrolin-4-yl)-4-hydroxy-2-oxo-3-pyrroline-1-acetamide
| Conditions | Yield |
|---|---|
| With hydrogen; Ru-carbon In water under 18751.5 Torr; for 20h; Ambient temperature; | A n/a B 45% C 24% D n/a |
- 114012-62-3
(1,5-dihydro-4-methoxy-2-oxo-2H-pyrrol-1-yl)acetamide
- 7491-74-9
2-oxo-1-pyrrolidine acetamide
| Conditions | Yield |
|---|---|
| With hydrogen; platinum on activated charcoal Yield given; | |
| Multi-step reaction with 2 steps 1: 96 percent / HCl / acetic acid / 2 h / 30 °C 2: H2 / 5percent Ru/C / H2O / 20 h / 18751.5 Torr / Ambient temperature View Scheme |
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Chemistry
Molecular structure of Piracetam (CAS NO.7491-74-9) is:
Product Name: Piracetam
CAS Registry Number: 7491-74-9
IUPAC Name: 2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Weight: 142.1558 [g/mol]
Molecular Formula: C6H10N2O2
EINECS: 231-312-7
Melting Point: 151-152 °C
Surface Tension: 51.4 dyne/cm
Density: 1.239 g/cm3
Flash Point: 200.8 °C
Enthalpy of Vaporization: 66.03 kJ/mol
Boiling Point: 408.3 °C at 760 mmHg
Vapour Pressure: 7.06E-07 mmHg at 25°C
Product Categories: Miscellaneous;API's
History
In 1964 , Piracetam (CAS NO.7491-74-9) was first synthesized by scientists at the Belgian pharmaceutical company UCB led by Dr Corneliu E. Giurgea. The drug was the first of the so-called nootropics ("smart drugs" or "cognitive enhancers"); that is, substances can increase brain activity, mental performance, and vigilance. The term nootropic was coined by Giurgea. Nootropil was launched clinically by UCB in the early 1970s and remains an important product of that company in Europe.
Uses
Piracetam (CAS NO.7491-74-9) is a drug which may enhance cognition and memory, may slow brain aging, may increase oxygen and blood flow to the brain,may improve Alzheimer's, may aid stroke recovery, Down's syndrome, dementia, and dyslexia, among other diseases and conditions. Piracetam may be classified as a psychoactive stimulant.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 10gm/kg (10000mg/kg) | Russian Pharmacology and Toxicology Vol. 47, Pg. 205, 1984. | |
| mammal (species unspecified) | LD50 | unreported | > 10gm/kg (10000mg/kg) | Russian Pharmacology and Toxicology Vol. 44, Pg. 22, 1981. | |
| mouse | LD50 | intraperitoneal | > 10gm/kg (10000mg/kg) | Pharmaceutical Chemistry Journal Vol. 23, Pg. 795, 1989. | |
| mouse | LD50 | intravenous | 9200mg/kg (9200mg/kg) | Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 465, 1983. | |
| mouse | LD50 | oral | 2gm/kg (2000mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 32, 1990. | |
| mouse | LD50 | subcutaneous | > 12gm/kg (12000mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 11(8), Pg. 132, 1977. | |
| rat | LDLo | oral | 5600mg/kg (5600mg/kg) | Farmaco, Edizione Pratica. Vol. 32, Pg. 47, 1977. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: UX9660500
Specification
Piracetam , its cas register number is 7491-74-9. It also can be called 1-Acetamido-2-pyrrolidinone ; 2-Ketopyrrolidine-1-ylacetamide ; 2-Oxo-1-pyrrolidineacetamide ; 2-Oxo-pyrrolidin-1-ylacetamide ; 2-Oxo-pyrrolidine acetamide ; 1-Pyrrolidineacetamide, 2-oxo- .It is very soluble in water.
