Detail of "74927-72-3"

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CAS Number:
74927-72-3
Name:
Benzeneacetic acid, α-[(3,5-dinitrobenzoyl)amino]-, (αR)-
Superlist Name:
(R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine
Molecular Structure:
Formula:
C₁₅H₁₁N₃O₇
Molecular Weight:
345.26
Synonyms:
Benzeneaceticacid, α-[(3,5-dinitrobenzoyl)amino]-,(R)-;(R)-(-)-N-(3,5-Dinitrobenzoyl)-α-phenylglycine;(R)-N-(3,5-Dinitrobenzoyl)phenylglycine;3,5-Dinitrobenzoyl-D-α-phenylglycine;N-(3,5-Dinitrobenzoyl)-D-phenylglycine;N-(3,5-Dinitrobenzoyl)-D-α-phenylglycine;
Density:
1.527 g/cm³
Melting Point:
217-218 ºC
Boiling Point:
569.4 °C at 760 mmHg
Flash Point:
298.2 °C
Appearance:
white to light yellow crystal powder
Safety:
22-24/25 Details

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Selection of the mobile phase for enantiomeric resolution via chiral stationary phase columns: Selection of the mobile phase for enantiomeric resolution via chiral stationary phase columns. Zief, M.; Crane, L. J.; Horvath, J. (Res. Lab., J. T. Baker Chem. Co., Phillipsburg, NJ 08865, USA). J.Some commonly used reagents like 74927-72-3 is used in this experiment. Liq. Chromatogr., 7(4), 709-30 (English) 1984. CODEN: JLCHD8. ISSN: 0148-3919. DOCUMENT TYPE: Journal CA Section: 66 (Surface Chemistry and Colloids) Section cross-reference(s): 21, 79 The optimization of enantiomeric resoln. by mobile phase variation was studied with the chiral stationary phase derived from R-N-(3,5-dinitrobenzoyl)phenylglycine covalently coupled to 5 m spherical 3-aminopropylsilica. Chromatog. was performed routinely with mobile phase compns. having polarities ￡2.5 without column deterioration. The relative strength of a solvent as a H acceptor was found to be an important basis for selection of the polar component in a binary mobile phase. The substitution of tert-BuOH for iso-PrOH or EtOH in an alc.-hexane mixt., for example, afforded improved sepn. factors with several enantiomers. In addn., the need for a polar mobile phase such as 50/50 CH2Cl2/hexane to minimize non-specific polar absorption of enantiomers was demonstrated. Enhancement of specific chiral interactins and suppression of interfering reactions were obtained with a no. of clin. relevant derivs. as model compds. .

Chromatographic separation of the enantiomers of acylated amines on chiral stationary phases: Chromatographic separation of the enantiomers of acylated amines on chiral stationary phases. Pirkle, William H.; Welch, Christopher J. (Sch. Chem. Sci., Univ. Illinois, Urbana, IL 61801, USA). J. Org. Chem.Several reagents with their cas registry numbers 88426-59-9 and 74927-72-3 are used here., 49(1), 138-40 (English) 1984. CODEN: JOCEAH. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 66 (Surface Chemistry and Colloids) Section cross-reference(s): 22 Enantiomers of acrylated amines are chromatog. resolved on a stationary phase made of (R)-N-(3,5-dinitrobenzoyl)phenylglycine covalently bound to g-aminopropylsilanized silica. Among the acylating agents studied, a-naphthoyl chloride generally serves well and has desirable chromophoric properties. The a-naphthamides of a series of primary amines, amino alcs., and amino acid derivs. are resolvable on the chiral stationary phase. Among the amines are various substituted cyclohexylamines. A chiral recognition model, consistent with present data, is described to rationalize the degree and sense of the obsd. chiral recognition. .