Products Categories
| CAS No.: | 75-45-6 |
|---|---|
| Name: | Chlorodifluoromethane |
| Article Data: | 92 |
| Molecular Structure: | |
|
|
|
| Formula: | CHClF2 |
| Molecular Weight: | 86.4687 |
| Synonyms: | Algeon 22;Algofrene 22;Algofrene 6;Arcton 22;Arcton 4;CFC 22;Chlorodifluoromethane;Daiflon 22;Difluoromonochloromethane;Dymel 22;F 22 (halocarbon);FC 22;FC 22 (halocarbon);FKW 22;Flugene22;Forane 22;Freon 22;Frigen 22;Fron 22;HFA 22;Haltron 22;Isceon 22;Isotron 22;Khladon 22;Korfron 22;Propellant 22;Refrigerant R 22;Solkane 22;Ucon 22; |
| EINECS: | 200-871-9 |
| Density: | 1.277 g/cm3 |
| Melting Point: | -146 °C |
| Boiling Point: | -40.8 °C |
| Solubility: | slightly soluble in water |
| Appearance: | Colourless gas |
| Hazard Symbols: |
 F
|
| Risk Codes: | 40-59 |
| Safety: | 23-59 |
| Transport Information: | UN 1018 |
| PSA: | 0.00000 |
| LogP: | 1.44780 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 75-45-6
Chlorodifluoromethane
| Conditions | Yield |
|---|---|
| With 2,2,2-trifluoroethanol In N,N,N,N,N,N-hexamethylphosphoric triamide decompn. in the presence of CF3CH2OH at reflux temp., 12 h; | 100% |
| In N,N,N,N,N,N-hexamethylphosphoric triamide |
| Conditions | Yield |
|---|---|
| nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 723 K; | A 98.3% B 0.6% |
| nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 673 K; | A 75.4% B 1.7% |
- 79-53-8
chloropentafluoroacetone
A
- 75-45-6
Chlorodifluoromethane
B
- 354-34-7
trifluoroacetyl fluoride
C
- 2925-22-6
2,2-difluoroacetyl fluoride
D
- 152239-89-9
C3HClF6O
| Conditions | Yield |
|---|---|
| With chlorine monofluoride; cesium fluoride 1.) -140 degC to -75 degC over 6 h, 2.) -75 degC, 2 h; Further byproducts given; | A n/a B n/a C n/a D 90% |
- 75-09-2
dichloromethane
- 7664-41-7
ammonia
A
- 74-90-8
hydrogen cyanide
B
- 75-10-5
Difluoromethane
C
- 75-45-6
Chlorodifluoromethane
D
- 124-38-9
carbon dioxide
E
- 201230-82-2
carbon monoxide
| Conditions | Yield |
|---|---|
| nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %); | A 81.8% B 0.1% C 0.6% D 10.4% E 6.8% |
| nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %); | A 66.2% B 0.2% C 1.4% D 12.9% E 18.8% |
| With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %); | A 64.6% B 0.3% C 0.2% D 0.6% E 0.8% |
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 100℃; | 68% |
- 75-09-2
dichloromethane
- 7664-41-7
ammonia
A
- 74-90-8
hydrogen cyanide
B
- 593-53-3
Methyl fluoride
C
- 75-10-5
Difluoromethane
D
- 75-45-6
Chlorodifluoromethane
E
- 124-38-9
carbon dioxide
| Conditions | Yield |
|---|---|
| With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K; | A 53.4% B 0.3% C 0.5% D 7.6% E 0.5% |
- 1717-59-5
2,2-difluoro-2-(fluorosulfonyl)acetic acid
- 1005-30-7
sodium 4-iodo-benzoate
A
- 75-45-6
Chlorodifluoromethane
B
- 120608-87-9
4-Iodo-benzoic acid difluoromethyl ester
| Conditions | Yield |
|---|---|
| With potassium chloride In acetonitrile at 50℃; for 2.5h; | A n/a B 45% |
- 79-38-9
Chlorotrifluoroethylene
- 152239-89-9
C3HClF6O
A
- 75-45-6
Chlorodifluoromethane
B
- 354-34-7
trifluoroacetyl fluoride
C
- 2925-22-6
2,2-difluoroacetyl fluoride
| Conditions | Yield |
|---|---|
| In trichlorofluoromethane for 18h; -135 degC to 25 degC; Further byproducts given; | A n/a B n/a C n/a D 40% |
| Conditions | Yield |
|---|---|
| In ethanol decompn. with alc. KOH at 35°C in 48h;; | A 24% B n/a |
| In ethanol |
- 75-43-4
Dichlorofluoromethane
- 1188-14-3
Triethylgerman
A
- 75-10-5
Difluoromethane
B
- 75-09-2
dichloromethane
C
- 75-46-7
trifluoromethan
D
- 75-45-6
Chlorodifluoromethane
E
- 994-28-5
triethylchlorogermane
| Conditions | Yield |
|---|---|
| With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere; | A n/a B n/a C 22% D 16% E n/a |
- 5308-25-81-Ethylpiperazine
- 793-24-81,4-Benzenediamine,N1-(1,3-dimethylbutyl)-N4-phenyl-
- 333-20-0Potassium thiocyanate
- 14047-28-09H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-
- 110-65-62-Butyne-1,4-diol
- 5535-48-8Phenyl vinyl sulfone
- 104632-26-0Pramipexole
- 34160-40-22-Pyridinecarboxaldehyde,6-bromo-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
Molecular Formula: CHClF2
Molecular Weight: 86.47
EINECS: 200-871-9
Index of Refraction: 1.278
Density: 1.277 g/cm3
Melting point: -146 °C
Boiling Point: 155 °C
Water solubility: Slightly soluble
Appearance: Colourless gas
Structure of Difluorochloromethane (CAS NO.75-45-6):
IUPAC Name: Chloro(difluoro)methane
Product Category of Difluorochloromethane (CAS NO.75-45-6): refrigerants;Organics;Refrigerant
Uses
Difluorochloromethane (CAS NO.75-45-6) is mainly used as mainlyPropellant, fumigant, insecticide. It was once commonly used as a propellant and in air conditioning applications.
Production
Difluorochloromethane (CAS NO.75-45-6) can be prepared from Chloroform : HCCl3 + 2HF → HCF2Cl + 2HCl .
Toxicity Data With Reference
| 1. | mmo-sat 33 pph/24H-C | TOLED5 Toxicology Letters. 2 (1978),1. | ||
| 2. | mma-sat 33 pph/24H-C | TOLED5 Toxicology Letters. 2 (1978),1. | ||
| 3. | ihl-rat LC50:35 pph/15M | HUTODJ Human Toxicology. 1 (1982),239. | ||
| 4. | ihl-mus LC50:28 pph/20M | TXAPA9 Toxicology and Applied Pharmacology. 59 (1981),64. | ||
| 5. | ihl-dog LCLo:70 pph | TXAPA9 Toxicology and Applied Pharmacology. 2 (1960),363. |
Consensus Reports
It is reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Hazard Codes: 
F
Risk Statements: 40-59
R40:Limited evidence of a carcinogenic effect.
R59:Dangerous to the ozone layer.
Safety Statements: 23-59
S23:Do not breathe vapour.
S59:Refer to manufacturer / supplier for information on recovery / recycling.
Mildly toxic by inhalation. Experimental reproductive effects. Mutation data reported. An asphyxiant in high concentrations. At elevated pressures, 50% mixtures with air are combustible although ignition is difficult. When heated to decomposition it emits toxic fumes of F− and Cl−.
Standards and Recommendations
OSHA PEL: TWA 1000 ppm
ACGIH TLV: TWA 1000 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 500 ppm (1800 mg/m3)
DOT Classification: 2.2; Label: Nonflammable Gas
Specification
Difluorochloromethane , its cas register number is 75-45-6. It also can be called Chlorodifluoromethane ; Fluorocarbon 22 ; Freon R-22 ; and Freon 22 . Difluorochloromethane (CAS NO.75-45-6) is shipped as a liquefied gas under its own vapor pressure, and is noncombustible. Difluorochloromethane can asphyxiate by the displacement of air. Contact with the liquid can cause frostbite.