Detail of "75-55-8"

Reference

Amphoteric acrylic ester-based latexes

Amphoteric acrylic ester-based latexes. Drake, Kenneth; Hammock, Richard A. (Union Carbide Corp. , USA). U.S. US 4451608 A 29 May 1984, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C08L033-06. NCL: 524560000. APPLICATION: US 82-393546 30 Jun 1982. DOCUMENT TYPE: Patent CA Section: 39 (Synthetic Elastomers and Natural Rubber) Amphoteric acrylic-based latexes are prepd. by partial imination of an acrylic base polymer latex contg. 10-35 % acrylic acid and/or methacrylic acid (based on the total wt. of monomers) with a specified amt. of an alkyleneimine. Thus, to a 3-L reactor equipped with a stirrer were charged 2.1 g Na dioctyl sulfylsuccinate, 848 g H2O, and 4 g (NH4)2S2O8. The mixt. was stirred and 2 feeds into the reactor were begun. The first of these feeds comprised 800 g Et acrylate and Bu acrylate and 120-200 g methacrylic acid and 8.0 g BuSH chain-transfer agent. The second feed contained 6.0 g Polystep RA-35S (a sulfonated ethoxylated nonylphenol) and 133 g H2O, and this feed was fed above the reaction surface for 2.5 h. The reaction was maintained at ~80° for 1 h. The base polymer latexes were dild. with H2O and then partially iminated by addn. of 50 mol% of propylenimine [75-55-8]. The latexes were titrated with NaOH and HCl to det. the pH of their base and acid solubilities, resp. The latexes were sol. in either acid (pH 1.9-3.4) or basic (pH 8.6-9.5) solns., and stable at neutral pH.

Urinary enzymes and isoenzymes of N-acetyl-b-D-glucosaminidase in the assessment of nephrotoxicity

Urinary enzymes and isoenzymes of N-acetyl-b-D-glucosaminidase in the assessment of nephrotoxicity. Halman, Julie; Price, Robert G.; Fowler, John S. L. (Queen Elizabeth Coll., London, UK). Sel. Top. Clin. Enzymol., Proc. (Sel.) Int. Congr., 4th, Meeting Date 1983, 435-44. Edited by: Werner, Mario; Goldberg, David M. de Gruyter: Berlin, Fed. Rep. Ger. (English) 1984. CODEN: 53MBAD. DOCUMENT TYPE: Conference CA Section: 4 (Toxicology) Section cross-reference(s): 1 The excretion of 5 urinary marker enzymes was measured daily in rats following i.p. injection of cis-platinum (I) [15663-27-1] (2.5, 5.0, or 7.5 mg/kg) or propylenimine (II) [75-55-8] (10, 20, or 30 mL/kg). The urinary enzyme pattern clearly distinguished the site of the damage of the 2 nephrotoxins. Renal papillary necrosis, following II injection, was the inability to conc. urine, resulting in an increased urine vol. Little change in the urine vol. followed the administration of I, but the proximal tubular damage. The brush border increased the excretion of alk. phosphatase and leucine aminopeptidase. In contrast, II administration increased the excretion of cytosolic marker b-D-glucosidase, while excretion of this enzyme remained at normal levels after I injection. Both chems. caused a small rise in the urinary N-acetyl-b-D-glucosaminidase (NAG) [9012-33-3] on day 1, with a further increase on day 3. The major peak of NAG excretion after I administration occurred on day 4 and the activity returned near-normal level 4 days later. II produced a more prolonged rise in the urinary NAG which returned to normal 13 days after administration.