75-56-9

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 328.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 36 ,1985,p. 227.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 36 ,1985,p. 227.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 11 ,1976,p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Carcinogenesis Studies (inhalation); Some Evidence: rat NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-267 ,1985. ; Clear Evidence: mouse NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-267 ,1985. . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Community Right-To-Know List. EPA Extremely Hazardous Substances List.

OSHA PEL: TWA 20 ppm
ACGIH TLV: TWA 2 ppm (sensitizer); Confirmed Animal Carcinogen with Unknown Revelance to Humans
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
DOT Classification:  3; Label: Flammable Liquid

For occupational chemical analysis use NIOSH: Propylene Oxide, 1612.

The Propylene oxide with CAS registry number of 75-56-9 is also known as Ethylene oxide, methyl-. The IUPAC name is 2-Methyloxirane. It belongs to product categories of Organics; Oxiranes; Simple 3-Membered Ring Compounds. Its EINECS registry number is 200-879-2. In addition, the formula is C₃H₆O and the molecular weight is 58.08. This chemical is a colourless liquid and should be sealed in cool, dry place away from light.

Physical properties about Propylene oxide are: (1)ACD/LogP: 0.33; (2)ACD/LogD (pH 5.5): 0.33; (3)ACD/LogD (pH 7.4): 0.33; (4)ACD/BCF (pH 5.5): 1.049; (5)ACD/BCF (pH 7.4): 1.049; (6)ACD/KOC (pH 5.5): 36.011; (7)ACD/KOC (pH 7.4): 36.011; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.399; (10)Molar Refractivity: 15.537 cm³; (11)Molar Volume: 64.275 cm³; (12)Surface Tension: 25.219 dyne/cm; (13)Density: 0.904 g/cm³; (14)Enthalpy of Vaporization: 27.35 kJ/mol; (15)Boiling Point: 32.899 °C at 760 mmHg; (16)Vapour Pressure: 572.478 mmHg at 25 °C.

Preparation of Propylene oxide. Firstly, propylene is conversed to chloropropanols and the reaction produces a mixture of 1-chloro-2-propanol and 2-chloro-1-propanol. Then the mixture is dehydrochlorinated to obtain the product.

Uses of Propylene oxide: it is used to produce 2-chloro-propan-1-ol. The reaction occurs with reagents ceric ammonium nitrate, tri-n-butyl benzyl ammonium chloride and solvent 2-methyl-propan-2-ol at ambient temperature for 2 hours. The yield is about 92%. Besides, it is used in the preparation of biological samples for electron microscopy. What's more, it is used in organic synthesis and manufacture of plastic. It is also used as solvents, chromatographic analysis of the standards.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. It is also harmful by inhalation, in contact with skin and if swallowed. It is extremely flammable and may cause heritable genetic damage or even cancer. During using it, obtain special instructions before use. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC1CO1
2. InChI: InChI=1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3
3. InChIKey: GOOHAUXETOMSMM-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LCLo	inhalation	2005ppm/4H (2005ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: NAUSEA OR VOMITING	AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
guinea pig	LCLo	inhalation	4000ppm/4H (4000ppm)	SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	AMA Archives of Industrial Health. Vol. 13, Pg. 228, 1956.
guinea pig	LD50	oral	660mg/kg (660mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(7), Pg. 76, 1981.
mammal (species unspecified)	LD50	oral	440mg/kg (440mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
man	TCLo	inhalation	1400gm/m3/10M (1400000mg/m3)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 48, 1971.
mouse	LC50	inhalation	1740ppm/4H (1740ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
mouse	LD50	intraperitoneal	175mg/kg (175mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
mouse	LD50	oral	440mg/kg (440mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.
rabbit	LD50	skin	1500uL/kg (1.5mL/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat	LC50	inhalation	4000ppm/4H (4000ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
rat	LD50	oral	380mg/kg (380mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.