Reference

In vitro lymphotoxicity and selective T cell immunotoxicity of high doses of acyclovir and its derivatives in mice

In vitro lymphotoxicity and selective T cell immunotoxicity of high doses of acyclovir and its derivatives in mice. Poluektova, L.; Krzystyniak, K.; Desjardins, R.; Flipo, D.; Fournier, M. ( Dep. Sci. Biol. Toxen, Univ. Quebec, Montreal, QC H3P 3C8, Can.). International Journal of Immunopharmacology, 18(6/7), 429-438 (English) 1996 Elsevier. CODEN: IJIMDS. ISSN: 0192-0561. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The antiviral drug acyclovir [9-(2-hydroxyethoxymethyl)guanine (ACV)], its 7-isomer (7-ACV) and its two derivs.: N2-acetyl ACV (ac-ACV) and N2, O-diacetyl ACV (diac-ACV) were examd. for their potential in vitro lymphotoxicity and in vivo immunotoxicity in mice. In vitro lymphotoxicity of ACV and its acetylated derivs. was low, whereas the 7-ACV isomer enhanced the in vitro cell proliferation in PHA-stimulated cultures.Several substances with their cas registry numbers 91702-61-3 and 75128-73-3 may be metioned in this study. Addn. of 2'-deoxyguanosine (dGuo) did not exhibit any inhibitory potential of ACV. However, redn. in the abs. no. of CD3+, CD8+, and CD25+ cells, but not Ig+ cells, was noted at high concns. of ACV and its derivs., suggesting a selective T cell cytotoxicity. Similarly, the in vivo exposure revealed selective T cell immunotoxicity of ACV and its derivs. since the reduced no. of Thy 1.2+ and CD8+ cells was not accompanied with any marked changes in the Ig+ population. The CD4+/CD8+ ratio was affected both in vitro and in vivo by high concns. of ACV. .