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| CAS No.: | 7519-36-0 |
|---|---|
| Name: | N-NITROSO-L-PROLINE |
| Article Data: | 37 |
| Molecular Structure: | |
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| Formula: | C5H8 N2 O3 |
| Molecular Weight: | 144.13 |
| Synonyms: | Proline,1-nitroso-, L- (8CI); 1-Nitroso-L-proline; N-Nitroso-L-proline;N-Nitrosoproline; NSC 109545 |
| Density: | 1.572g/cm3 |
| Melting Point: | 108-109°C |
| Boiling Point: | 391.692oC at 760 mmHg |
| Flash Point: | 190.688oC |
| Safety: | Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Many nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NITROSO COMPOUNDS. |
| PSA: | 69.97000 |
| LogP: | 0.15470 |
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Chemistry
IUPAC Name: 1-Nitrosopyrrolidine-2-carboxylic acid
The molecular formula of Nitrosoproline (CAS NO.7519-36-0) is C5H8N2O3.
The molecular weight of Nitrosoproline (CAS NO.7519-36-0) is 144.13.
Synonyms of Nitrosoproline (CAS NO.7519-36-0): 1-Nitrosoproline ; Proline, 1-nitroso- ; 1-Nitroso-pyrrolidine-2-carboxylic acid
Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
Apperance: Colourless Plates
Index of Refraction: 1.629
Density: 1.57 g/ml
Flash Point: 190.7 °C
Boiling Point: 391.7 °C
Melting Point: 108-109 °C
Uses
Nitrosoproline (CAS NO.7519-36-0) is a nitrosoamino acid with oncogenicity.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 203mg/kg (203mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES | Journal of Medicinal Chemistry. Vol. 16, Pg. 583, 1973. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 303.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Many nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NITROSO COMPOUNDS.