Reference

Studies on amino acids and peptides - VII

Studies on amino acids and peptides - VII. Syntheses of aspartame and thioaspartame. Yde, B.; Thomsen, I.; Thorsen, M.; Clausen, K.; Lawesson, S. O. (Chem. Inst., Univ. Aarhus, Aarhus DK-8000, Den.). Tetrahedron, 39(24), 4121-6 (English) 1983. CODEN: TETRAB. ISSN: 0040-4020. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Z-Asp(OCH2Ph)-OH (Z = PhCH2O2C) was coupled with H-Phe-OMe.HCl by Lawesson's Reagent (LR) in CH2Cl2 contg. Et3N to give 74% protected aspartame Z-Asp(OCH2Ph)-Phe-OMe, which was thionated by LR in benzene at 80° to give 93% protected thioaspartame ZNHCH(CH2CO2CH2Ph)CS-Phe-OMe. Z-Asp(OCMe3)-ONSu (NSu = succinimido) was coupled with H-Phe-OMe.In this experiment, several chemicals are used like 88621-57-2 and 7524-50-7 HCl to give 93% Z-Asp(OCMe3)-Phe-OMe (I), which was deblocked by HF/anisole to give 98% H-Asp-Phe-OMe (aspartame). I was thionated by LR at 80° to give 92% ZNHCH(CH2CO2CMe3)CS-Phe-OMe, which was deblocked by HF/anisole to give 87% H2NCH(CH2CO2H)CS-Phe-OMe (thioaspartame). .

Preparation of thiazole derivatives as agrochemical fungicides

Preparation of thiazole derivatives as agrochemical fungicides.Some chemicals with cas registry numbers like 187681-66-9 and 7524-50-7 are also used. Akyama, Shigeaki; Suzuki, Hiroyuki; Yasumi, Yoshiaki; Takeyama, Toshiaki; Watanabe, Junichi; Ooya, Hiroshi; Nishioka, Masanori; Furusato, Takashi (Nissan Chemical Ind Ltd, Japan). Jpn. Kokai Tokkyo Koho JP 09031069 A2 4 Feb 1997 Heisei, 26 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D277-56. ICS: A01N043-78; C07D417-06. APPLICATION: JP 1995-186959 24 Jul 1995. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 5 The title compds. I [X = halo; W = O, etc.; R1 = alkyl, halo; R2 = OR3, etc.; R3 = cycloalkyl, etc.] are prepd. I [X = Cl; R1 = methyl; W = O; R2 = Q1] at 500 ppm gave complete control of Pseudoperonospora cubensis. .