Detail of "75338-42-0"

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Preparation of 7-(3,6-diazabicyclo[3

Preparation of 7-(3,6-diazabicyclo[3.1.0]hexyl)-4-oxo-3-quinolinecarboxylic acids and related compounds as antibacterials. Moon, Soon Ku; Lee, Gwan Sun; Ryoo, Eui Sang; Chang, Young Kil; Moon, Young Ho; Kim, Sang Tae; Chun, Jong Pil; Koh, Joon Hyung; Gil, Young Hwan (Hanmi Pharmaceutical Co., Ltd.In this study，75338-42-0 is also used., S. Korea). PCT Int. Appl. WO 9212155 A1 23 Jul 1992, 81 pp. DESIGNATED STATES: W: AU, CA, HU, JP, RU, US; RW: AT, CH, DE, DK, ES, FR, GB, IT, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2.Several reagents such as 75338-42-0 is used here. CLASS: ICM: C07D487-08. ICS: C07D471-04; C07D215-56; A61K031-47; A61K031-435. APPLICATION: WO 92-KR3 14 Jan 1992. PRIORITY: KR 91-446 14 Jan 1991; KR 91-17787 10 Oct 1991; KR 91-25396 30 Dec 1991. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 27, 63 Title compds. [I; R1 = H, protective group; R2 = H, (alkyl)amino, OH, alkoxy, SH, alkylthio, halo; R3 = (cyclo)alkyl, alkenyl, haloalkyl, hydroxyalkyl, MeO, (alkyl)amino, Me2N, (substituted) Ph; R4, R5, R7 = H, alkyl; X = N, CR6; R6 = H, OH, Me, cyano, NO2, MeO, halo; R3R6 = NHCH2CHMe, OCH2CHMe, SCH2CHMe, CH2CH2CHMe], were prepd. Thus, 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarb oxylic acid and 1,6-dimethyl-3,6-diazabicyclo[3.1.0]hexane acetate (prepn. starting from citraconic anhydride and PhCH2NH2 given) were stirred overnight in pyridine at 50-60° to give 28% title compd. II. II showed a min. inhibitory concn. of 1.563 mg/mL against Pseudomonas aeruginosa 9027. Pharmaceutical formulations contg. various I were prepd. ..

Preparation of 7-(3,6-diazabicyclo[3

Preparation of 7-(3,6-diazabicyclo[3.1.0]hexyl)-4-oxo-3-quinolinecarboxylic acids and related compounds as antibacterials. Moon, Soon Ku; Lee, Gwan Sun; Ryoo, Eui Sang; Chang, Young Kil; Moon, Young Ho; Kim, Sang Tae; Chun, Jong Pil; Koh, Joon Hyung; Gil, Young Hwan (Hanmi Pharmaceutical Co., Ltd.In this study，75338-42-0 is also used., S. Korea). PCT Int. Appl. WO 9212155 A1 23 Jul 1992, 81 pp. DESIGNATED STATES: W: AU, CA, HU, JP, RU, US; RW: AT, CH, DE, DK, ES, FR, GB, IT, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2.Several reagents such as 75338-42-0 is used here. CLASS: ICM: C07D487-08. ICS: C07D471-04; C07D215-56; A61K031-47; A61K031-435. APPLICATION: WO 92-KR3 14 Jan 1992. PRIORITY: KR 91-446 14 Jan 1991; KR 91-17787 10 Oct 1991; KR 91-25396 30 Dec 1991. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 27, 63 Title compds. [I; R1 = H, protective group; R2 = H, (alkyl)amino, OH, alkoxy, SH, alkylthio, halo; R3 = (cyclo)alkyl, alkenyl, haloalkyl, hydroxyalkyl, MeO, (alkyl)amino, Me2N, (substituted) Ph; R4, R5, R7 = H, alkyl; X = N, CR6; R6 = H, OH, Me, cyano, NO2, MeO, halo; R3R6 = NHCH2CHMe, OCH2CHMe, SCH2CHMe, CH2CH2CHMe], were prepd. Thus, 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarb oxylic acid and 1,6-dimethyl-3,6-diazabicyclo[3.1.0]hexane acetate (prepn. starting from citraconic anhydride and PhCH2NH2 given) were stirred overnight in pyridine at 50-60° to give 28% title compd. II. II showed a min. inhibitory concn. of 1.563 mg/mL against Pseudomonas aeruginosa 9027. Pharmaceutical formulations contg. various I were prepd. ..