Detail of "7554-65-6"

CAS Number:
7554-65-6
Name:
1H-Pyrazole, 4-methyl-
Superlist Name:
4-Methylpyrazole
Molecular Structure:
Formula:
C₄H₆N₂
Molecular Weight:
82.10
Synonyms:
Pyrazole,4-methyl- (6CI,7CI,8CI);4-Methyl-1H-pyrazole;Antizol;Fomepizole;Fomepizolum;
EINECS:
231-445-0
Density:
1.062 g/cm³
Melting Point:
13°C
Boiling Point:
243.6 °C at 760 mmHg
Flash Point:
96.1 °C
Appearance:
clear colourless to yellowish liquid after melting
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38
Safety:
26-36-24/25 Details
Transport Information:
UN 2810

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Reference

Inhibition of N-nitrosodimethylamine metabolism by ethanol and other inhibitors in the isolated perfused rat liver: Inhibition of N-nitrosodimethylamine metabolism by ethanol and other inhibitors in the isolated perfused rat liver. Tomera, John F.; Skipper, Paul L.; Wishnok, John S.; Tannenbaum, Steven R.; Brunengraber, Henri (Dep. Nutr. Food Sci., Massachusetts Inst. Technol., Cambridge, MA 02139, USA). Carcinogenesis (London), 5(1), 113-16 (English) 1984. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of several potential inhibitors of N-nitrosodimethylamine (NDMA) [62-75-9] metab. were studied in isolated perfused rat livers. Low concns. of EtOH [64-17-5] (<0.5 mM) strongly inhibit hepatic metab. of NDMA. This effect did not require the metab. of EtOH. The metab. and toxicity of NDMA may therefore be influenced by the intake of alc. as well as by EtOH produced endogenously by the intestinal flora. Other compds. found to inhibit NDMA metab. include n-propanol [71-23-8], tert-butanol [75-65-0], 4-methylpyrazole [7554-65-6], aminotriazole [61-82-5], and acetaldehyde [75-07-0].

Effects of pyrazole and 3-amino-1,2,4-triazole on the metabolism and toxicity of dimethylnitrosamine in the rat: Effects of pyrazole and 3-amino-1,2,4-triazole on the metabolism and toxicity of dimethylnitrosamine in the rat. Phillips, John C.; Lake, Brian G.; Gangolli, Sharat D.; Grasso, Paul; Lloyd, Alun G. (Br. Ind. Biol. Res. Assoc., Carshalton Beeches/Surrey, Engl.). J. Natl. Cancer Inst., 58(3), 629-33 (English) 1977. CODEN: JNCIAM. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Pretreatment of rats with pyrazole [288-13-1] or 3-amino-1,2,4-triazole (3-AT) [61-82-5], known inhibitors of alc. metab., profoundly inhibited the metab. of dimethylnitrosamine (DMN) [62-75-9], both in terms of 14CO2 excretion and of decline in blood concn. Addnl., 4-methylpyrazole [7554-65-6], tetraethylthiuram disulfide (disulfiram) [97-77-8], methanol [67-56-1], and ethanol [64-17-5] inhibited the metab. of DMN in the whole animal. In parallel expts. with 14C-labeled aminopyrine [58-15-1], no substantial inhibitory effect was found with pyrazole, 3-AT, or disulfiram pretreatment. Investigations into the effects of pyrazole and 3-AT pretreatment on the acute toxicity and hepatotoxicity of DMN showed that pyrazole significantly increased the median lethal dose (LD50) of DMN and provided substantial protection against the hepatotoxicity of DMN, in that centrilobular necrosis was not seen at dose levels of DMN up to 25 mg/kg and early histochem. changes indicative of liver injury were not obsd. at a dose level of 15 mg DMN/kg. 67-56-1 and 97-77-8 are just another two chemicals used in this study. In contrast, 3-AT pretreatment did not affect the LD50 of DMN or provide any protection against the hepatotoxicity of DMN. Further, although both inhibitors delayed the incorporation of radioactivity from DMN-14C into hepatic subcellular organelles, pyrazole was significantly more effective than was 3-AT. .

Detail of "7554-65-6"

1H-Pyrazole, 4-methyl-

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