CAS No.75607-67-9,Fludarabine phosphate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	75607-67-9
Name:	Fludarabine phosphate
Article Data:	9

Formula:	C₁₀H₁₃FN₅O₇P
Molecular Weight:	365.215
Synonyms:	Fludarabine phosphate (JAN/USP);Fludarabine 5-monophosphate;9-beta-D-Arabinofuranosyl-2-fluoroadenine 5-(dihydrogen phosphate);Trimeric Sodium Phosphate;[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid;2-Fluoro-ARA AMP;Fludarabine phosphate [USAN:BAN];Fludarabine monophosphate;9-beta-Arabinofuranosyl-2-fluoroadenine-5-phosphate;Fludura;9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-;2-Fluoroadenine arabinoside 5-monophosphate;fludarabine hcl;
EINECS:	616-242-0
Density:	2.39 g/cm³
Melting Point:	203°C(dec.)(lit.)
Boiling Point:	864.2 °C at 760 mmHg
Flash Point:	476.4 °C
Solubility:	Soluble in DMSO or water at 5mg/ml
Hazard Symbols:	T
Risk Codes:	R25
PSA:	195.88000
LogP:	-1.14270

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Chemistry

IUPAC Name: [5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular Formula: C₁₀H₁₃FN₅O₇P
Molecular Weight: 365.21 g/mol
Classification Code: Antimetabolites; Antimetabolites, antineoplastic; Antineoplastic; Antineoplastic Agents; Drug / Therapeutic Agent; Human Data; Immunologic Factors; Immunosuppressive agents; Noxae
Product Categories: Active Pharmaceutical Ingredients; Antineoplastics; Antineoplastic; API
XLogP3: -3.1
H-Bond Donor: 5
H-Bond Acceptor: 12
Surface Tension: 130.7 dyne/cm
Density: 2.39 g/cm³
Flash Point: 476.4 °C
Enthalpy of Vaporization: 131.58 kJ/mol
Boiling Point: 864.2 °C at 760 mmHg
Vapour Pressure of Fludarabine phosphate (CAS NO.75607-67-9): 7.38E-32 mmHg at 25 °C

Uses

Fludarabine phosphate (CAS NO.75607-67-9) is a chemotherapy drug used in the treatment of hematological malignancies. It is highly effective in the treatment of chronic lymphocytic leukemia.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	18750mg/kg/5D (18750mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE	Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986.
man	TDLo	intravenous	11655mg/kg/5D (11655mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986.
man	TDLo	intravenous	17760mg/kg/5D (17760mg/kg)	BRAIN AND COVERINGS: DEMYELINATION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: COMA	Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986.
mouse	LD50	intravenous	1236mg/kg (1236mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. PB83-195685,
women	LDLo	intravenous	14245mg/kg/5D (14245mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: EXCITEMENT SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Cancer Treatment Reports. Vol. 70, Pg. 1449, 1986.
women	TDLo	intravenous	23125mg/kg/5D (23125mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Cancer Treatment Reports. Vol. 70, Pg. 1225, 1986

Specification

Fludarabine phosphate (CAS NO.75607-67-9), its Synonyms are Fludarabine monophosphate ; 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine ; 2-Fluoro-ARA AMP ; 2-Fluoroadenine arabinoside 5'-monophosphate ; 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) ; 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate ; Fludara ; 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- .