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CAS No.: | 75747-14-7 |
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Name: | Telatinib |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C31H43N3O8 |
Molecular Weight: | 585.698 |
Synonyms: | 17-(Allylamino)-17-demethoxygeldanamycin;17-(Allylamino)-17-desmethylgeldanamycin;17-(Allylamino)geldanamycin;17-Demethoxy-17-allylaminogeldanamycin;17AAG;BMS 722782;CP 127374;KOS 953;NSC 330507;Tanespimycin; |
Density: | 1.21 g/cm3 |
Melting Point: | 201-203 °C |
Boiling Point: | 797.8 °C at 760 mmHg |
Flash Point: | 436.3 °C |
Solubility: | DMSO: soluble |
Appearance: | Dark purple solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 22-24/25-36-26 |
PSA: | 166.28000 |
LogP: | 3.95760 |
Conditions | Yield |
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In N,N-dimethyl-formamide at 20℃; | 99% |
In chloroform at 20℃; for 18h; | 99% |
In dichloromethane at 23℃; | 95% |
17-allylamino-17-demethoxygeldanamycin
Conditions | Yield |
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With Dess-Martin periodane In chloroform for 1h; Heating; | 96% |
With Dess-Martin periodane In dichloromethane at 20℃; |
C5H10ClNO*ClH
17-allylamino-17-demethoxygeldanamycin
C5H11NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: C5H10ClNO*ClH In dichloromethane for 2h; Stage #3: With water In dichloromethane | 92% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: C5H10ClNO*ClH In dichloromethane for 2h; | 92% |
C3H6ClNO*ClH
17-allylamino-17-demethoxygeldanamycin
C3H7NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: C3H6ClNO*ClH In dichloromethane for 2h; Stage #3: With water In dichloromethane | 91% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: C3H6ClNO*ClH In dichloromethane for 2h; | 91% |
17-allylamino-17-demethoxygeldanamycin
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)‐19‐(allylamino)‐13,20,22‐trihydroxy‐8,14‐dimethoxy‐4,10,12,16‐tetramethyl‐3‐oxo‐2‐azabicyclo[1 6.3.1]docosa‐1(22),4,6,10,18,20‐hexaen‐9‐yl carbamate
Conditions | Yield |
---|---|
With sodium dithionite; water In ethyl acetate for 0.5h; | 90% |
With sodium dithionite; water In ethyl acetate at 20℃; for 2h; | 85% |
With sodium dithionite; water In ethyl acetate at 22℃; for 1h; Product distribution / selectivity; | 74% |
β-Alanine acid chloride hydrochloride
17-allylamino-17-demethoxygeldanamycin
C3H7NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: β-Alanine acid chloride hydrochloride In dichloromethane for 2h; Stage #3: With water In dichloromethane | 83% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: β-Alanine acid chloride hydrochloride In dichloromethane for 2h; | 83% |
17-allylamino-17-demethoxygeldanamycin
Trichloroacetyl isocyanate
11-carbamate-17-(allylamino)-17-demethoxygeldanamycin
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1.5h; | 80% |
dimethylaminoacetyl chloride hydrochloride
17-allylamino-17-demethoxygeldanamycin
C4H9NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h; Stage #3: With water In dichloromethane Product distribution / selectivity; | 79% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h; | 79% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In MeTHF for 0.75h; Stage #2: dimethylaminoacetyl chloride hydrochloride In MeTHF at 0℃; for 3h; Product distribution / selectivity; |
N,N-dimethylaminoacetyl chloride hydrochloride
17-allylamino-17-demethoxygeldanamycin
C4H9NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: N,N-dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h; Stage #3: With water In dichloromethane | 66% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: N,N-dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h; | 66% |
1-aminocyclopropanecarbonyl chloride hydrochloride
17-allylamino-17-demethoxygeldanamycin
C4H7NO2*C31H45N3O8*ClH
Conditions | Yield |
---|---|
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h; Stage #2: 1-aminocyclopropanecarbonyl chloride hydrochloride In dichloromethane for 2h; Stage #3: With water In dichloromethane | 62% |
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h; Stage #2: 1-aminocyclopropanecarbonyl chloride hydrochloride In dichloromethane for 2h; | 62% |
IUPAC Name: [(8Z,12Z,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate
Molecular Formula: C31H43N3O8
Molecular Weight: 585.69g/mol
Density: 1.21
Melting Point: 201-203°C
The Cas Register Number of Telatinib is 75747-14-7 .The chemical synonyms of Telatinib (CAS NO. 75747-14-7) are Geldanamycin,17-demethoxy-17-(2-propenylamino)- ; CP 127374 ; Allylaminogeldanamycin ; 17-(Allylamino)-17-demethoxygeldanamycin ; 17-(Allylamino)-17-desmethoxygeldanamycin ; 17-(Allylamino)-17-dimethoxygeldanamycin ; 17-Allylaminogeldanamycin ; 17-AG .The molecular structure of Telatinib (CAS NO. 75747-14-7) is.
It is a substance that is being studied in the treatment of cancer, specific young patients with certain types of leukemia or solid tumors, especially kidney tumors.
Hazard Codes:Xi
Risk Statements: 36/37/38
R36: Irritating to eyes.
R37: Irritating to respiratory system
R38: Irritating to skin.
Safety Statements: 22-24/25-36-26
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
The extinguishing agent of Telatinib (CAS NO. 75747-14-7) are dry powder, foam, sand, carbon dioxide, water mist.