Detail of "7575-82-8"

Reference

The identification of the N-oxidized metabolic products of amantadine in the rabbit

The identification of the N-oxidized metabolic products of amantadine in the rabbit. Belanger, P. M.; Grech-Belanger, O. (Ec. Pharm., Univ. Laval, Ste.-Foy, Que., Can.). Can. J. Pharm. Sci., 12(4), 99-102 (English) 1977. CODEN: CNJPAZ. ISSN: 0008-4190. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) N-hydroxy-1-aminoadamantane (I) [31463-23-7] and 1-nitrosoadamantane (II) [22734-10-7] were identifiedin the ethreal ext. at neutral pH after incubation of amantadine-HCl (III-HCl) [665-66-7] with hepatic microsomal prepns. of male and female rabbits. 1-Nitroadamantane (IV) [7575-82-8] was also identified in the alk. ext. of incubation of III. Compds. I and II were oxidized to IV in alk. soln. The thin-layer chromatog., gas-liq. chromatog., and mass spectral characteristics of these 3 new metabolic products of III were compared with those of ref. compds. prepd. chem. Compds.I,II, and III were excreted in the urine of rabbits dosed with III. Metabolite I was also found in the conjugated form.

Effect of high coverages and anomalous mechanism of the electroreduction of nitro derivatives of adamantane and noradamantane

Effect of high coverages and anomalous mechanism of the electroreduction of nitro derivatives of adamantane and noradamantane. Leibzon, V. N.; Mendkovich, A. S.; Mairanovskii, S. G.; Klimova, T. A. (Inst. Org. Khim. im. Zelinskogo, Moscow, USSR). Nov. Polyarogr., Tezisy Dokl. Vses. Soveshch. Polyarogr., 6th, 21-2. Edited by: Stradins, J. "Zinatne": Riga, USSR. (Russian) 1975. CODEN: 34DIA8. DOCUMENT TYPE: Conference CA Section: 72 (Electrochemistry) Studies were made on a Hg electrode for the following compds.: 1-nitroadamantane (I) [7575-82-8], 1,3-dinitroadamantane (II) [61735-09-9], and 3,7-dinitronoradmantane (III) [61734-79-0]. When pH was increased from 3 to 12 for I, the degree of inhibition of electroredn. by the adsorbed depolarizer was const. However, a sharp potential drop obsd. on polarograms denoted that desorption of the depolarizer did not occur but its redn. from the adsorbed layer. During electroredn. of III in solns. with pH 4-8, a change in the process mechanism was noted along with the potential growth, and as a result, a decrease of the limiting diffusion current was shown on polarograms of II at potentials >0.9 V. The change in the electroredn. mechanism was connected with the competition of protonation processes of anion-radicals. With increase of potential, the no. of electrons participating in the process decreased from 6 to 2.