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Oligosaccharide structural specificity of the soluble agglutinin released from guinea pig colonic epithelial cells

Oligosaccharide structural specificity of the soluble agglutinin released from guinea pig colonic epithelial cells. Pierce-Cretel, Annick; Izhar, Morchedai; Nuchamowitz, Yael; Strecker, Gerard; Montreuil, Jean; Spik, Genevieve; Mirelman, David (Lab. Chim. Biol., Univ. Sci. Tech. Lille I, Villeneuve d'Ascq 59655, Fr.). FEMS Microbiol. Lett., 20(2), 237-42 (English) 1983. CODEN: FMLED7. ISSN: 0378-1097. DOCUMENT TYPE: Journal CA Section: 15 (Immunochemistry) Guinea pig colonic epithelial cells release a sol. lectin capable of agglutinating numerous strains of Shigella and Escherichia coli as well as other bacteria. Using pure oligosaccharides and glycopeptides with well defined structures to inhibit the agglutination of S. flexneri 1b by the sol.There are some commonly used reagents with their cas registry numbers 7578-25-8 and 84949-22-4 in this article. intestinal lectin, it was shown that the latter recognizes different structural types. Inhibition by human milk glycoprotein glycopeptides with biantennary glycans of the N-acetyl lactosamine type was dependent on the simulaneous presence of unsubstituted terminal nonreducing galactose residues and of a fucose residue a-1,6-linked to the asparagine-conjugated N-acetylglucosamine residues and of a fucose residue a-1,6-linked to the asparagine-conjugated N-acetylglucosamine residue. Unsubstituted terminal nonreducing galactose was also a determinant for inhibition by human milk oligosaccharides. Oligosaccharides possessing the Man(a1-2)Man structure inhibited more effectively than those with a Man(a1-3)Man sequence. The fact that these different structural motifs were all inhibitory raises the problem of the possible existence of a multispecific lectin or of several different lectins in the guinea pig colonic mucosa mediating bacterial adherence. .

Urinary oligosaccharides during pregnancy and lactation

Urinary oligosaccharides during pregnancy and lactation. II. Structural analysis of oligosaccharides isolated from the urine of a blood group A, secretor, woman during pregnancy and lactation. Hallgren, Peter; Lundblad, Arne (Dep. Clin. Chem., Univ. Hosp., Lund, Swed.). J. Biol. Chem., 252(3), 1023-33 (English) 1977. CODEN: JBCHA3. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) Twenty different oligosaccharides were isolated from urine collected from an A, Le(a- b+), secretor woman during pregnancy and subsequent lactation. Nine of these had been found previously in the milk of Le(a- b+) individuals. Three new fucose-contg. oligosaccharides, denoted lacto-N-neo-trifucoheptaose II, lacto-N-neo-difucohexaose I, and lacto-N-difucohexaose IV are described. Three new myo-inositol-contg. 7578-25-8 and 32581-31-0 are also in the experiment. oligosaccharides which are characteristic for pregnancy were also isolated and their structures characterized. Three oligosaccharides contg. only glucose were found and partially characterized. The isolation procedure included ultrafiltration, gel chromatog. on Sephadex G-25, and preparative paper chromatog. Structural detn. involved sugar and methylation analyses, and combined gas-liq. chromatog.-mass spectrometry. Anomeric configurations were deduced from optical rotations an by comparison with authentic samples. .