Detail of "75821-71-5"

CAS Number:
75821-71-5
Name:
1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-, calcium salt (2:1)
Molecular Structure:
Formula:
C₃₄H₂₄CaCl₂N₄O₄
Molecular Weight:
663.56276
Synonyms:
1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-, calcium salt (9CI);Argun L;Irritren;Lonazolac calcium;SNK 874;
EINECS:
278-322-8
Boiling Point:
525.1 °C at 760 mmHg
Flash Point:
271.4 °C

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Package:25kgs drum

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Biopharmaceutical studies of lonazolac acetic acid ester and lonazolac argininate: Biopharmaceutical studies of lonazolac acetic acid ester and lonazolac argininate. Ham, Kwang Su; Lee, Wan Ha; Yang, Jae Heon (Coll.Several substances are used for example 140674-54-0 and 75821-71-5 which are their cas registry numbers. Pharm., Sung Kyun Kwan Univ., Suwon 440-746, S. Korea). Yakche Hakhoechi, 21(2), 103-10 (Korean) 1991. CODEN: YAHAEX. ISSN: 0259-2347. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 28 Two new prodrugs of lonazolac, lonazolac acetic acid ester (I) and lonazolac argininate, were prepd. and examd. for physicochem. properties and biopharmaceutical characteristics. The prodrugs were stable in solid state and lonazolac argininate showed higher dissoln. rate than lonazolac Ca in both artificial gastric and intestinal juices. These prodrugs have greater analgesic effect than that of lonazolac-Ca in mice, and increased anti-inflammatory activities in rats. In addn., ulcerogenic effects and acute toxicity of these prodrugs were lower than those of lonazolac-Ca. I showed larger area under the plasma concn.-time curves (AUC) than that of lonazolac. Therefore, it was suggested that these prodrugs of lonazolac have advantages over lonzolac-Ca for not only enhanced bioavailability but also decreased ulcerogenic and toxic effects. .