Detail of "75957-60-7"

CAS Number:
75957-60-7
Name:
L-Tyrosine,L-arginyl-L-lysyl-L-a-glutamyl-L-valyl-
Superlist Name:
Splenopentin
Molecular Structure:
Formula:
C31H51 N9 O9
Molecular Weight:
693.79
Synonyms:
L-Tyrosine,N-[N-[N-(N2-L-arginyl-L-lysyl)-L-a-glutamyl]-L-valyl]-; Splenopentin; Splentin
Density:
1.42 g/cm³

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Contrasting effects of thymopentin and splenopentin on the capacity of female mice to reject syngeneic male skin: Contrasting effects of thymopentin and splenopentin on the capacity of female mice to reject syngeneic male skin. Goldberg, Ellen H.; Goldstein, Gideon; Harman, Delia B.; Boyse, Edward A. (Sch. Med., Univ. New Mexico, Albuquerque, NM 87131, USA). Transplantation, 38(1), 52-5 (English) 1984. CODEN: TRPLAU. ISSN: 0041-1337. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 15 Thymopentin (TP-5) [69558-55-0] and splenopentin (SP-5) [75957-60-7], pentapeptide analogs of thymopoietin and splenin, resp., which represent positions 32-36 of the parent mols., were compared for effects on the capacity of C3H/HeJ female mice to reject C3H/HeJ male skin (the H-Y rejection response). The H-Y rejection response in young, thymus-intact female mice was heightened by TP-5 and SP-5. Neither TP-5 nor SP-5 affected the increased H-Y rejection response in splenectomized female mice. TP-5 lowered the raised H-Y rejection response in thymectomized female mice, whereas SP-5 did not. Thus, not only do these structurally very similar immunoregulators differ in their particular functions, but the overall effect of these functions in vivo depends on the immune status of the recipient.

Conformational states of thymopentin and some of its synthetic analogs: Conformational states of thymopentin and some of its synthetic analogs. Akhmedov, N. A.; Khalilova, N. M.; Popov, E. M. (Azerb. State Univ., Baku, USSR). Mol. Biol. (Moscow), 21(1), 159-63 (Russian) 1987. CODEN: MOBIBO. 69558-55-0 and 107787-22-4 which are cas registry numbers of chemicals are mentioned. ISSN: 0026-8984. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 34 Spatial structures of thymopentin [69558-55-0] and its synthetic analogs, Lys-Arg-Asp-Val-Tyr [107787-21-3], Arg-Lys-Glu-Val-Tyr [75957-60-7], and Arg-Lys-Gly-Val-Tyr [107787-22-4], were investigated by theor. conformational anal. The conformational properties indicated a low energy state with 5 different backbone forms. .