Detail of "7652-46-2"

Reference

Field desorption mass spectrometric characterization of thiol conjugates related to the oxidative metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m-anisidide

Field desorption mass spectrometric characterization of thiol conjugates related to the oxidative metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m-anisidide. Gaudich, K.; Przybylski, M. (Inst. Org. Chem., Univ. Mainz, Mainz D-6500, Fed. Rep. Ger.). Biomed. Mass Spectrom., 10(4), 292-9 (English) 1983. CODEN: BMSYAL. ISSN: 0306-042X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 25 The primary microsomal oxidn. product of m-AMSA [51264-14-3], N1'-methanesulfonyl-N4'-(9-acridinyl)-3'-methoxy-2',5'-cyclohexadien e-1'',4'-diimine [87764-57-6], was prepd. by MnO2 oxidn. 51264-14-3 which is the cas registry number of some chemical is mentioned. of m-AMSA and reaction with equimolar amts. of GSH [70-18-8], L-cysteine [52-90-4], N-acetylcysteine [616-91-1], and N-acetylcysteine Me ester [7652-46-2] to form m-AMSA-(5')-thiol conjugates linked to the PhNH2 ring. Field desorption mass spectra of the conjugates provided abundant [MH]+ ions, and characteristic fragment ions by cleavage at the thioether bonds and at the g-Glu-Cys linkage. The formation of m-AMSA-thiol (PhNH2 ring) vs. thiolysis (acridine ring) conjugates depends on the rate of enzymic oxidn. of m-AMSA and GSH levels in vivo. .

Studies on the molecular toxicology of buta-1,3-diene and isoprene epoxides

Studies on the molecular toxicology of buta-1,3-diene and isoprene epoxides. Bleasdale, Christine; Small, Rowena D.; Watson, William P.; Wilson, Joanne; Golding, Bernard T. (Department Chemistry, University Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK). Toxicology, 113(1-3), 290-293 (English) 1996 Elsevier. CODEN: TXCYAC.Several substances with their cas registry numbers 7652-46-2 and 40560-13-2 may be metioned in this study. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 23 Reactions of ethenyloxirane with amino (RNH2) and thiol (R'SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3. In contrast, 2-ethenyl-2-methyloxirane reacts with amino (RNH2) and thiolate (R'S-) nucleophiles in methanol by regioselective SN2 attack at C-3 ("neo-pentyl" position). However, in pure water or methanol SN1 reaction occurs mainly at C-2. .