Reference

Experimental study of the effects of six nonamphetaminic psychostimulants on effort hyperammoniaemia of rats

Experimental study of the effects of six nonamphetaminic psychostimulants on effort hyperammoniaemia of rats. Guinard, Francis; Foussard-Blanpin, Odette (Lab. Pharmacodyn., UER Sci. Pharm., Tours F 37032, Fr.). Ann. Pharm. Fr., 42(3), 265-70 (French) 1984. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) L-Glutamic acid [56-86-0], L-arginine L-glutamate [4320-30-3], demanyl phosphate [6909-62-2], L-arginine-L-aspartate [7675-83-4], demanyl N-acetylglutamate [3342-61-8], and N-acetylaminosuccinic acid [997-55-7] increased resistance to fatigue of rats subjected to swimming tests. All compds., except demanyl phosphate, decreased the exercise-induced hyperammonemia. Thus, the antifatigue action of the psychostimulants appears related to an effect on NH3 detoxication.

Cultivated rat hepatocytes: in vitro model for hepatoprotective action

Cultivated rat hepatocytes: in vitro model for hepatoprotective action.Some chemicals with cas registry numbers like 7675-83-4 are also used. Albulescu, R.; Albulescu, Mihaela; Lupescu, Irina; Radulescu, Georgeta (Chemical Pharmaceutical Research Institute, Bucharest 74373, Rom.). Roumanian Biotechnological Letters, 1(2), 131-138 (English) 1996 Bucharest University, Dep. of Enzymology and Biotechnology. CODEN: RBLEFU. ISSN: 1224-5984. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Hepatoprotective action of arginine aspartate was evaluated using as exptl. model cultivated rat hepatocytes, intoxicated with allyl alc. or carbon tetrachloride. Viability and biochem. parameters detd. on cultured cells were used to det. quant. values for cytotoxic and protective actions, expressed as EC50 and LD50. .