CAS No.7681-49-4,Sodium fluoride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	7681-49-4
Name:	Sodium fluoride

Formula:	NaF
Molecular Weight:	41.9882
Synonyms:	Natrium fluoride;Luride-SF;Fluorocid;T-Fluoride;Chemifluor;Studafluor;Sodium fluoride [UN1690] [Poison];Flursol;Minute-Gel;Fluorid sodny;SO-Flo;Karigel;Flozenges;Ossin;Sodium fluoride [ISO];Thera-flur;Fungol B;Fluoraday;Duraphat;Super-dent;Trisodium trifluoride;Credo;F1-Tabs;Nafeen;Gleem;Flura-gel;Fluorigard;Nufluor;Sodium Fluoride (NaF);Fluonatril;Pennwhite;Villiaumite;Pediaflor;NaF;Iradicav;Rafluor;Rescue squad;Fluorineed;Na frinse;Flux;Sodium fluorure [French];FDA 0101;Sodium hydrofluoride;Liquiflur;Fludent;Sodium fluoride, solid;Flurexal;Koreberon;Thera Flur;Luride lozi-tabs;Flura-loz;Osteofluor;Fluorol;Ossalin;Prodent;Lemoflur;Predent;Fluoritab;Fluorure de sodium [French];Point two;Sodium fluoride cyclic dimer;Floridine;GEL II;Florocid;Act;Fluoride, sodium;Osteopor-F;Fluorinse;Sodium fluoride, solid (DOT);Luride SF;NCI-C55221;Les-Cav;Roach salt;Neutra Care;Sodium fluoride (JAN/USP);Fluorident;Fluorid sodny [Czech];Zymafluor;Sodiumfluoride;
EINECS:	231-667-8
Density:	2.558 g/cm³
Melting Point:	993 °C(lit.)
Boiling Point:	1695 °C
Flash Point:	1704°C
Solubility:	0.5 M (20 °C) in water; soluble in HF; insoluble in ethanol
Appearance:	White solid
Hazard Symbols:	T
Risk Codes:	25-32-36/38
Safety:	23-24/25-45-36-22
Transport Information:	UN 1690 6.1/PG 3
PSA:	0.00000
LogP:	-2.99600

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Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Standards and Recommendations

OSHA PEL: TWA 2.5 mg(F)/m³
ACGIH TLV: TWA 2.5 mg(F)/m³; BEI: 3 mg/g creatinine of fluorides in urine prior to shift; 10 mg/g creatinine of fluorides in urine at end of shift.
NIOSH REL: TWA (Inorganic Fluorides) 2.5 mg(F)/m³
DOT Classification: 6.1; Label: KEEP AWAY FROM FOOD

Analytical Methods

For occupational chemical analysis use NIOSH: Fluorides, 7902; Acids, Inorganic, 7903.

Specification

The Sodium fluoride, also known as Alcoa sodium fluoride, is the inorganic compound with the formula NaF. Its EINECS registry number is 231-667-8. With the CAS registry number 7681-49-4, it is a colorless solid. Sodium fluoride is soluble in potassium hydroxide and fluorides, soluble in water 0.25 g/L at 20 °C but insoluble in organic solvents.

Physical properties of Sodium fluoride are: (1)H-Bond Donor: 0; (2)H-Bond Acceptor: 1; (3)Rotatable Bond Count: 0; (4)Exact Mass: 41.988173; (5)MonoIsotopic Mass: 41.988173; (6)Topological Polar Surface Area: 0; (7)Heavy Atom Count: 2; (8)Formal Charge: 0; (9)Complexity: 2; (10)Covalently-Bonded Unit Count: 2.

Preparation of Sodium fluoride: Sodium fluoride can be prepared by neutralizing hydrofluoric acid or hexafluorosilicic acid (H₂SiF₆), byproducts of the production of superphosphate fertilizer. Neutralizing agents include sodium hydroxide and sodium carbonate. Alcohols are sometimes used to precipitate the NaF:

HF + NaOH → NaF + H₂O

In addition, Sodium fluoride can also be produced by reaction of hydrofluoric acid, hydrated alumina, and sodium carbonate. It is commonly produced by mixing sodium aluminate soln with liquid or gaseous hydrogen fluoride. Normally manufactured by the reaction of hydrofluoric acid with soda ash or caustic soda, with control of pH essential and proper agitation necessary to obtain the desired crystal size.

Uses of Sodium fluoride: Fluoride salts are used to enhance the strength of teeth by the formation of fluorapatite, a naturally occurring component of tooth enamel. sodium fluoride is used as a cleaning agent, e.g. as a "laundry scour". Like other fluorides, Sodium fluoride finds use in desilylation in organic synthesis. The fluoride is the reagent for the synthesis of fluorocarbons. In medical imaging, fluorine-18-labelled Sodium fluoride is used in positron emission tomography (PET).

When you are using this chemical, please be cautious about it as the following:
Sodium fluoride is toxic if swallowed and is irritating to eyes and skin. You should not breathe its dust and its gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). What's more, you must avoid contact with skin and eyes. Whenever you will contact it, you should wear suitable protective clothing. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1S/FH.Na/h1H;/q;+1/p-1
(2)InChIKey: PUZPDOWCWNUUKD-UHFFFAOYSA-M
(3)Canonical SMILES: [F-].[Na+]

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	110mg/kg (110mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 16, Pg. 483, 1987.
cat	LDLo	subcutaneous	14mg/kg (14mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
dog	LDLo	intraperitoneal	50mg/kg (50mg/kg)		U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951,
dog	LDLo	subcutaneous	155mg/kg (155mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
domestic animals - goat/sheep	LD50	oral	100mg/kg (100mg/kg)		New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982.
domestic animals - goat/sheep	LD50	oral	100mg/kg (100mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982.
frog	LDLo	subcutaneous	448mg/kg (448mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 124, Pg. 133, 1937.
guinea pig	LDLo	subcutaneous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
human	LDLo	oral	71mg/kg (71mg/kg)	BEHAVIORAL: TREMOR MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES MUSCULOSKELETAL: OTHER CHANGES	"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1361, 1989.
human	LDLo	oral	75mg/kg (75mg/kg)		Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1033, 1966.
human	TDLo	intradermal	14ug/kg (.014mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE	Revue Medicale de Liege. Vol. 12, Pg. 408, 1957.
human	TDLo	oral	214ug/kg (.214mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Revue Medicale de Liege. Vol. 12, Pg. 408, 1957.
man	TDLo	oral	1662mg/kg (1662mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	JAMA, Journal of the American Medical Association. Vol. 222, Pg. 816, 1972.
monkey	LD50	intravenous	26600ug/kg (26.6mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 99, 1965.
mouse	LD50	intraperitoneal	38mg/kg (38mg/kg)	GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.
mouse	LD50	intravenous	50830ug/kg (50.83mg/kg)	GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.
mouse	LD50	oral	57mg/kg (57mg/kg)		Shika Gakuho. Journal of Dentistry. Vol. 80, Pg. 1519, 1980.
mouse	LD50	subcutaneous	115ug/kg (.115mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68(3), Pg. 55P-74P, 1972.
mouse	LDLo	skin	300mg/kg (300mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 183, Pg. 427, 1936.
rabbit	LD50	oral	200mg/kg (200mg/kg)		Journal of Economic Entomology. Vol. 61, Pg. 751, 1968.
rabbit	LDLo	subcutaneous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
rat	LD50	intraperitoneal	22mg/kg (22mg/kg)		U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951,
rat	LD50	intravenous	26mg/kg (26mg/kg)	SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Toxicology and Applied Pharmacology. Vol. 3, Pg. 278, 1961.
rat	LD50	oral	52mg/kg (52mg/kg)		National Technical Information Service. Vol. UR-3490-95,
rat	LD50	subcutaneous	175mg/kg (175mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968.
women	LDLo	oral	90mg/kg (90mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: FLUID INTAKE BEHAVIORAL: MUSCLE WEAKNESS	JAMA, Journal of the American Medical Association. Vol. 81, Pg. 811, 1923.
women	LDLo	oral	360mg/kg (360mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	JAMA, Journal of the American Medical Association. Vol. 100, Pg. 97, 1933.
women	TDLo	oral	7mg/kg (7mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	British Medical Journal. Vol. 1, Pg. 886, 1936.