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CAS No.: | 7681-76-7 |
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Name: | RONIDAZOLE |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C6H8N4O4 |
Molecular Weight: | 200.154 |
Synonyms: | 1H-Imidazole-2-methanol,1-methyl-5-nitro-, carbamate (ester) (9CI);Imidazole-2-methanol,1-methyl-5-nitro-, carbamate (ester) (8CI);1-Methyl-2-carbamoyloxymethyl-5-nitroimidazole;Dugro;MCMN;Ridzol;Ridzol P;Ridzole;Ronida BT; |
EINECS: | 231-675-1 |
Density: | 1.65 g/cm3 |
Melting Point: | 167-169° |
Boiling Point: | 502.3 °C at 760 mmHg |
Flash Point: | 257.6 °C |
Safety: | 22-24/25 |
PSA: | 115.96000 |
LogP: | 1.14710 |
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate
ronidazole
Conditions | Yield |
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With ammonium hydroxide In dichloromethane at 0 - 10℃; for 3h; Inert atmosphere; |
Conditions | Yield |
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Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: ammonium hydroxide / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere View Scheme |
Conditions | Yield |
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In ethanol; acetone for 2.5h; Reflux; | 94% |
Conditions | Yield |
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In ethanol; acetone for 24h; Reflux; | 89% |
potassium tetrachloroplatinate(II)
ronidazole
(NO2CCHNC(CH2OC(O)NH2)N(CH3))2PtCl2
Conditions | Yield |
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In water solid ligand added to aq. soln. of K2(PtCl4), stirred at 50 °C for 1 h; ppt. filtered, washed with EtOH/Et2O, Et2O, dried in vac.; elem. anal.; | 81% |
Conditions | Yield |
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In ethanol; acetone for 2.5h; Reflux; | 81% |
Conditions | Yield |
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In ethanol; acetone for 4h; Reflux; | 78.86% |
Conditions | Yield |
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In ethanol; acetone for 24h; Reflux; | 78.67% |
Conditions | Yield |
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In ethanol; acetone for 4h; Reflux; | 76.86% |
Conditions | Yield |
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In ethanol; dichloromethane; acetone for 4h; Reflux; | 74.96% |
1. | mmo-sat 3 µg/plate | CBINA8 Chemico-Biological Interactions. 49 (1984),27. | ||
2. | mmo-smc 500 ppm | MUREAV Mutation Research. 86 (1981),243. | ||
3. | orl-rat LD50:3400 mg/kg | VMDNAV Veterinarno-Meditsinski Nauki. 22 (7)(1985),90. | ||
4. | ipr-rat LD50:1500 mg/kg | VMDNAV Veterinarno-Meditsinski Nauki. 22 (7)(1985),90. |