Reference

cDNA and protein sequences of human Acyl-CoA synthetases and its use for diagnosis, treatment and drug screening for cancers

All Rights Reserved. cDNA and protein sequences of human Acyl-CoA synthetases and its use for diagnosis, treatment and drug screening for cancers. 76896-80-5 and 922199-48-2 are also occured in this study. Mashima, Tetsuo; Tsuruo, Takashi (Japanese Foundation for Cancer Research; Takeda Pharmaceutical Company Limited, Japan). PCT Int. Appl. WO 2007010628 A1 25 Jan 2007, 167pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2005-JP13908 22 Jul 2005. DOCUMENT TYPE: Patent CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 7, 13, 14 This invention provides cDNA and protein sequences of human Acyl-CoA synthetases. The Acyl-CoA synthetases inhibitor, triacsin c, can induce apoptosis and repress cell proliferation of human solid cancer caused by mutation in p53 gene. The Acyl-CoA synthetases provided in this invention can be used for diagnosis, treatment and drug screening for cancers. .