Detail of "7700-27-8"

CAS Number:
7700-27-8
Name:
Benzene,1-chloro-4-(phenylmethoxy)-
Molecular Structure:
Formula:
C₁₃H₁₁ClO
Molecular Weight:
218.68
Synonyms:
p-(Benzyloxy)chlorobenzene;p-Chlorophenyl benzyl ether;Ether,benzyl p-chlorophenyl (6CI,8CI);1-Chloro-4-(phenylmethoxy)benzene;4-Chlorophenyl benzyl ether;Benzyl 4-chlorophenyl ether;Benzyl p-chlorophenylether;
Density:
1.175 g/cm³
Melting Point:
70 °C
Boiling Point:
321 °C at 760 mmHg
Flash Point:
149 °C
Hazard Symbols:
Xi

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1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol tartrate: 1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol tartrate. (Yodogawa Pharmaceutical Co., Ltd.Several substances are used for example 7700-27-8 and 90017-89-3 which are their cas registry numbers., Japan). Jpn. Kokai Tokkyo Koho JP 58222077 A2 23 Dec 1983 Showa, 2 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D295-08. APPLICATION: JP 82-106046 18 Jun 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Vasodilating (known) title compd. (I) was prepd. by reaction of a-(4-benzylpiperidino)propionaldehyde (II) with 4-PhCH2OC6H4MgX (III; X = halo) followed by hydrogenation of the resulting 1-(4-benzyloxyphenyl)-2-(4-benzylpiperidino)propan-1-ol (IV) in the presence of HO2CCH(OH)CH(OH)CO2H (V) and redn. catalysts. Thus, autoclaving 38.4 g 4-benzylpiperidine with 22.2 g Et3N and 46.8 g MeCHBrCH(OEt)2 3 h at 150° gave 82% II di-Et acetal (VI). Hydrolysis of 6 g VI in 0.1 HCl at 50° gave 4.1 g II. Addn. of 1.6 g II to a mixt. of 13.1 g III (X = Cl) and 1.5 g Mg in THF at 10° gave 19.5 g IV, which was hydrogenated in 50% EtOH contg. 3.5 g V and Pd/C to give 30.1 g I. .