Reference

Veterinary compositions for treatment of mammary infections of cattle and goats

Veterinary compositions for treatment of mammary infections of cattle and goats. Lacombe, Jean Francois Paul Louis (Fr. ). Eur. Pat. Appl. EP 97580 A1 4 Jan 1984,18 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE.Chemicals with cas numbers 1406-11-7 and 114-07-8 also play role. (French). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K037-54. ICI: A61K037-54, A61K037-02, A61K031-71. APPLICATION: EP 83-401232 15 Jun 1983. PRIORITY: FR 82-10927 16 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Veterinary compns. with antimicrobial properties consist of a mixt. of 2 antibiotics and an enzyme and are used for the treatment of mammary infections. Thus, a compn. contained a mixt. of erythromycin thiocyanate [7704-67-8] 200 mg (corresponding to the base), and lysozyme-HCl [9066-59-5] 30 mg, polymyxin B sulfate [1405-20-5] 50,000 IV, and pH 6.8 buffer q.s.p. to 100 mL. The compn. may be used for the treatment of infections from both gram pos. and gram neg. bacteria. The effectiveness of the compn. was demonstrated in the treatment of infection in cows. The animals tolerated the compn. well. .

Erythromycin A cyclic 11,12-carbonate

Erythromycin A cyclic 11,12-carbonate. Biedrzycki, Marek; Dahlig, Halina; Chmielnicki, Piotr; Glabski, Tadeusz (Tarchominskie Zaklady Farmaceutyczne "Polfa", Pol.). Eur. Pat. Appl. EP 119431 A1 26 Sep 1984, 18 pp. DESIGNATED STATES: R: DE, GB, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07H017-08. APPLICATION: EP 84-101239 7 Feb 1984. PRIORITY: PL 83-240514 10 Feb 1983. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Erythromycin A cyclic 11,12-carbonate (I) was prepd. by transesterification of 1,2-diol or 1,3-diol carbonate by anhyd. erythromycin (II) in anhyd. 7704-67-8 is the cas registry number of certain chemical which is used as reagents here. org. solvent in the presence of a phase transfer catalyst. Thus, 100.0 g II contg. <2% H2O was dissolved in PhMe and the obtained soln. azeotropically dried. K2CO3 8.0, KHCO3 15.0, PhCH2NEt3Cl 2.0, and ethylene carbonate 40 g were added and the whole was stirred at 40° for 6 h to give 83% I. .