Detail of "77146-42-0"

CAS Number:
77146-42-0
Name:
BMY 30120
Molecular Structure:
Formula:
C₂₂H₃₀Cl₂N₁₀^.2C₆H₈NO₃P
Molecular Weight:
851.6594
Synonyms:
Chlorhexidine phosphanilate [USAN];1,1-Hexamethylenebis(5-(p-chlorophenyl)biguanide) (p-aminophenyl)phosphonate (1:2);Phosphonic acid,(4-aminophenyl)-,compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,- 11,13-tetraazatetradecanediimidamide (2:1);2,4,11,13-Tetraazatetradecanediimidamide, N,N-bis(4-chlorophenyl)-3,12-diimino-, (4-aminophenyl)phosphonate (1:2);WP 973;CHLORHEXIDINE PHOSPHANILATE;2-[N-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]-1-(4-chlorophenyl)guanidine; (4-aminophenyl)phosphonic acid;
Boiling Point:
699.3 °C at 760 mmHg
Flash Point:
376.7 °C

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Topical chlorhexidine diphosphanilate (WP-973) in burn wound sepsis: Topical chlorhexidine diphosphanilate (WP-973) in burn wound sepsis. McManus, Albert T.; Denton, Camille L.; Mason, Arthur D., Jr. (US Army Inst. Surg. Res., Fort Sam Houton, TX 78234, USA). Arch. Surg. (Chicago), 119(2), 206-11 (English) 1984. CODEN: ARSUAX. ISSN: 0004-0010. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 WP-973 (I) [77146-42-0], as a 2% cream, was studied for its therapeutic activity in 2 rat models of fatal burn wound infection. Control treatments were infection and placebo cream; infection only; infection and 1% sulfadizine silver; and burning only. Activity against Pseudomonas aeruginosa or Proteus mirabillis was tested in surface-inoculated rats with 20% scalds. Treatment were initiated 24 h or 4 h, resp., after inoculation. 77146-42-0 is also in the experiment. Pseudomonas-Infected rats were treated once a day for 10 days. Proteus-Infected rats were treated once a day for 5 days. In these exptl. models, chlorhexidine diphosphanilate was equal to silver sulfadiazine, an established topical chemotherapeutic agent. In vitro activity was examd. using bacteremia isolated from 65 burned patients. Using agar diffusion trench plates, chlorhexidine diphosphanilate was active against all strains. No evidence of cross-resistance between sulfonamide and chlorhexidine diphosphanilate its components was obsd. .