Detail of "77174-66-4"

Reference

Mass spectrometry on the structure determination of some drug metabolites

Mass spectrometry on the structure determination of some drug metabolites. Nakagawa, Yuzo (Shionogi Res. Lab., Japan). Iyo Masu Kenkyukai Koenshu, 9, 39-44 (Japanese) 1984. CODEN: KIMKDN. DOCUMENT TYPE: Journal; General Review CA Section: 63 (Pharmaceuticals) A review with 2 refs. of mass spectrometric studies on 1-[1-[2-(3-chlorobenzyloxy)phenyl]vinyl]imidazole-HCl (I) [77174-66-4] and its metabolites.

Studies on antifungal activity of 710674-S, a new antimycotic imidazole

Studies on antifungal activity of 710674-S, a new antimycotic imidazole. II. Therapeutic effect on experimental dermatophytosis. Tawara, Katsuya; Sunagawa, Norio; Takema, Morio (Shionogi Res. Lab., Shionogi and Co., Ltd., Osaka 553, Japan). Shinkin to Shinkinsho, 25(4), 351-7 (Japanese) 1984. CODEN: SHSHBL. ISSN: 0583-0516. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 In vivo antifungal activities of cream and gel forms of 710674-S (I) [77174-66-4] were evaluated by topical application on an exptl. model of dermatophytosis (Arthroderma vanbreuseghemii) in guinea pigs. Evaluation was made in terms of (a) av. lesion score and (b) rate of appearance of neg. cultures from infected skin sections. I cream and gel forms (0.5, 1 and 2%) were effective in treating the dermatophyte model after 10 consecutive days of treatment initiated 5 days after infection began. Efficacy was in the order of 2%, 1% and 0.5% in both forms. I 1% cream was almost bioequivalent to the com. clotrimazole 1% cream. The effect of I 1% gel seemed to be similar to those of I cream and clotrimazole 1% cream.