Detail of "77181-69-2"

CAS Number:
77181-69-2
Name:
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-[(1E)-2-bromoethenyl]-
Molecular Structure:
Formula:
C11H13 Br N2 O6
Molecular Weight:
0
Synonyms:
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-(2-bromoethenyl)-,(E)-; (E)-5-(2-Bromovinyl)-1-(b-D-arabinofuranosyl)uracil; 1-b-D-Arabinofuranosyl-(E)-5-(2-bromovinyl)uracil; 1-b-D-Arabinofuranosyl-5-(2-bromovinyl)uracil;5-Bromovinyl-araU; Arabinosyl (E)-5-(2-bromovinyl)uracil; BVAU; BVaraU;Bravavir; Brovavir; SQ 32756; Sorivudine; Usevir; YN 72

Display：

sorivudine p-INNList-64,1990;r-INNList-31,1991; Brovavir，Usevir，BVAU (+)-1-β-D-arabinofuranosyl-5-[(E)-2-bromovinyl]uracil C11H13BrN2O6

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Dermatological preparation with improved bioavailability: Dermatological preparation with improved bioavailability. Kreiner, Christine F.; Loebering, Hans Georg (Thilo, Dr., und Co. G.m.b.H., Fed. Rep. Ger.). Ger. Offen. DE 3233638 A1 15 Mar 1984, 16 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K009-08; A61K009-12; A61K031-70; A61K031-505; A61K031-66; A61K031-62. APPLICATION: DE 82-3233638 10 Sep 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Liq. 540-11-4 which is the cas registry number is also used here. or gelled topical pharmaceuticals with a base of short-chain alcs. (35-98% by vol.) and H2O (up to 50% by vol.) have improved drug bioavailability if 1-50% of C12-21 satd. and/or unsatd. lipophilic alcs. and 1-15% of triglycerides or partial glycerides of C6-21 fatty acids, optionally contg. OH groups, are incorporated. The gelled prepns. contain 0.1-2% of a cellulose ether. The preferred lipophilic alc. is ricinoleyl alc. [540-11-4] and the preferred glyceride is an ethoxylated partial glyceride of C6-12 satd. fatty acids. When tested by application to the back of guinea pigs infected with herpes simple 1 virus, a gel of bromovinylarabinofuranosyluracil [77181-69-2] 2, Me Pr cellulose 2, 5% propanediol 5, and H2O to 100 g was inactive, whereas a spray contg. 2 g of the virucide in 20 mL ricinoleyl alc and 90% EtOH to 100 mL had max. activity. .

Production of E-5-(2-bromovinyl)-1-b-D-arabinofuranosyluracil 5'-triphosphate as an antitumor and antiviral agent: Production of E-5-(2-bromovinyl)-1-b-D-arabinofuranosyluracil 5'-triphosphate as an antitumor and antiviral agent. (Ruth, Jerry L., USA). Jpn. Kokai Tokkyo Koho JP 58148894 A2 5 Sep 1983 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07H019-10. ICA: A61K031-70. APPLICATION: JP 82-29743 25 Feb 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 33 The title compd. (I) [79551-90-9] is prepd. E-5-(2-Bromovinyl)-1-b-D-arabinofuranosyluracil [77181-69-2] was dissolved in PO(OMe)3 at -10°, and POCl3 was added. The reaction product was added to DMF contg. tris(tributylammonium) pyrophosphate [88499-44-9]. The title compd. produced was isolated from the medium by column chromatog. 88499-44-9 and 77181-69-2 are just another two chemicals used in this study. Its antiviral and antitumor activity seemed to be attributable to its inhibitory effect on DNA polymerase. .