Reference

Antibacterial poly(6-amino-6-deoxy)cyclodextrins

Antibacterial poly(6-amino-6-deoxy)cyclodextrins. Tsujihara, Kenji; Kurita, Hironori (Tanabe Seiyaku Co., Ltd., Japan). Japan. Kokai JP 52138580 18 Nov 1977 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C08B037-16. APPLICATION: JP 76-55949 14 May 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 33 The poly(6-amino-6-deoxy)cyclodextrins (I, n = 5 or 6) are novel antimicrobial agents. The min. inhibitory concn. of I (n = 5).5HCl [66002-59-3] and I (n = 6).6HCl (II) [64963-69-5] was 25 and 50 mg/mL, resp. for Pseudomonas aeruginosa. Thus, II was prepd. by treatment of b-cyclodextrin [7585-39-9] in pyridine with mesitylenesulfonyl chloride [773-64-8], followed by adding dild. HCl to give white cryst. hexa(6-O-mesitylenesulfonyl)-b-cyclodextrin (III) [65041-84-1]. III dissolved in 15% NH3-MeOH solns. was heated at 70-5° for 3 days in a sealed tube to give II.

Antibacterial poly(6-O-mesitylenesulfonyl) cyclodextrins

Antibacterial poly(6-O-mesitylenesulfonyl) cyclodextrins. Tsujihara, Kenji; Kurita, Hironori (Tanabe Seiyaku Co., Ltd., Japan). Japan. Kokai JP 52138581 18 Nov 1977 Showa, 3 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C08B037-16. APPLICATION: JP 76-55950 14 May 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The poly(6-O-mesitylenesulfonyl)cyclodextrins I (R = Q; n = 5 or 6) are antibacterial agents. Thus, b-cyclodextrin [7585-39-9] in pyridine was reacted with mesitylenesulfonyl chloride [773-64-8], followed by addn. of dil. HCl to give white hexa(6-O-mesitylenesulfonyl)-b-cyclodextrin [65041-84-1], m. 189.5°.