Detail of "7730-20-3"

CAS Number:
7730-20-3
Name:
Tryptophan, 6-fluoro-
Molecular Structure:
Formula:
C₁₁H₁₁FN₂O₂
Molecular Weight:
222.2156
Synonyms:
DL-Tryptophan, 6-fluoro-;Tryptophan, 6-fluoro-, DL- (8CI);6-Fluoro-DL-tryptophan;DL-6-Fluorotryptophan;DL-6-Fluorotryptophane;NSC 9364;
EINECS:
231-788-6
Density:
1.442 g/cm³
Melting Point:
280-285 °C (dec.)(lit.)
Boiling Point:
450.7 °C at 760 mmHg
Flash Point:
226.4 °C
Appearance:
almost white to beige powder
Hazard Symbols:
T
Safety:
24/25 Details

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Effect of DL-6-fluorotryptophan on sleep and wakefulness in the rat: Effect of DL-6-fluorotryptophan on sleep and wakefulness in the rat. Nakajima, Kunihiro (Sch. Med., Iwate Med. Univ., Morioka 020, Japan). Iwate Igaku Zasshi, 38(4), 489-500 (Japanese) 1986. CODEN: IIZAAX. ISSN: 0021-3284. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Seven male Wistar rats with permanently implanted EEG electrodes were used. After a 24-h polygraph recording following i.p. injection of the DL-6-fluorotryptophan (I) [7730-20-3] vehicle, 100 mg/kg of I was i.p. administered and the polygraph recording was made continuously for 48 h. The total sleep (TS) time and slow-wave sleep (SWS) time during a 2-h period and the paradoxical sleep (PS) time during a 3-h period after I administration decreased and the wakefulness (WAK) time during a 3-h period after I administration increased as compared with controls. During a 12-h period after I administration, there were differences in TS and PS times between the I-treated group and the control, but not in SWS between both groups. However, the cumulative time of either TS, SWS, or PS during a 24-h period after I administration was not different from the controls. No abnormal behavior was obsd. during the state of WAK after I administration.