Detail of "7735-56-0"

Reference

Electrochemical preparation of hydroquinone thiocarbonic ester

Electrochemical preparation of hydroquinone thiocarbonic ester. Belyi, O. V.; Karlovskaya, N. E.; Segeda, A. S.; Galagan, R. D.; Belaya, L. M. (Cherkas. Pedagog. Inst., Cherkassy, USSR). Ukr. Khim. Zh. (Russ.There are some reagents with their cas registry numbers 7735-56-0 and 1762-95-4 are used in this study. Ed.), 52(7), 726-8 (Russian) 1986. CODEN: UKZHAU. ISSN: 0041-6045. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 25, 28, 80 The electrochem. thiocyanation of hydroquinone was accomplished, and the properties of the obtained products were studied. The starting materials for the synthesis were hydroquinone and NH4SCN in aq.-alc. solns. of HCl. The thiocyanation occurs by ionic electrophilic and ionic nucleophilic mechanisms. Polarization curves of the hydroquinone and NH4SCN in solns., together and sep., were plotted to study the reaction mechanism. The spectra were studied of a mixt. of 5-hydroxy-2-oxo-1,3-benzoxathiole; quinone; and hydroquinone in aq. and alc. solns. at a concn. of each substance of 1 ′ 10-4 mol/L. The exptl. data showed that each of the above-mentioned substances in the mixt. maintains its individual spectra. This allows one to det. the qual. compn. of a mixt. from the absorption spectra of the substances. .

Preparation of benzo[1,3]oxathiol-2-ones as neuroprotective agents

Preparation of benzo[1,3]oxathiol-2-ones as neuroprotective agents. Jaquith, James B.; Villeneuve, Gerald; Bureau, Patrick; Boudreault, Alain (Aegera Therapeutics Inc., Can.). PCT Int. Appl. WO 2005012281 A1 10 Feb 2005, 51 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D327-04. ICS: A61P025-28; A61K031-39. APPLICATION: WO 2004-CA1421 29 Jul 2004. PRIORITY: US 2003-PV490528 29 Jul 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. I [wherein R4 - R7 = H, halo, cyano, azide, formyl, (un)substituted alkyl, (hetero)aryl, biphenyl, XR8 or amino; R4 and R5 may form a ring; R6 and R7 may form a ring; X = O or S; R8 = H, (un)substituted alkyl, acyl, (hetero)aryl or sulfonyl; with some compds. excluded, and pharmaceutically acceptable salts thereof] were prepd. as neuroprotective agents. I have been tested in several biol. assays to show their ability to protect SCG neurons and to inhibit protein phosphatases. For example, treatment of 2,5-dichlorobenzoquinone with thiourea followed by NaOAc afforded II (R = H) in 30% yield. This compd. underwent nucleophilic addn. with Bu isocyanate to give carbamate II (R = C(O)NHBun) in 80% yield, which exhibited rescue of SCG neurons from Taxol killing (IC50 = 8 mM) and inhibition against SHP1 and CD45 phosphatase (IC50 = 42.7 mM and 62.2 mM, resp.). 7735-56-0 is just another one chemical used in this study. Therefore, I and pharmaceutical compns. thereof are useful in the treatment and prevention of neuronal disorders of the central and peripheral nervous systems. .